... contribute directly to significant antiarrhythmic or antifibrillatory activity. 16 06 1986 20 08 1986 5 6 2008 © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...

...Gregory A. Kopia; Edward M. Driscoll; King-Fai Yeung; Benedict R. Lucchesi Pirlimycin adenylate (U-63,440) is a clindamycin analog possessing antiarrhythmic activity. In the anesthetized dog, the sustained ventricular tachycardia produced by ouabain intoxication is converted to a normal sinus...

... only slight local anesthetic, antiarrhythmic and CNS-depressant activity. At 40 mg/kg the benzyl nitrile derivative was superior to lidocaine in protecting against chloroform-induced arrhythmias. The methyl nitrile analog was less active than the benzyl nitrile analog in most parameters examined...