... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Angiotensin I Angiotensin II...

... was to assess the role of angiotensin II (Ang II) in functional closure of DA since its action may not be conditioned by oxygen. Experiments were performed with wild-type fetal and neonatal mice, using whole-body freezing technique to assess DA caliber in vivo. Transcripts for Ang II type 1 (AT 1 R) and type 2...

...Man Si; Jiaxi Xu; Fan Zhang; Chuan Wang; Xiaona Du; Hailin Zhang Background/Aims: The slow component of the delayed rectifier K + current ( I Ks ) is one of the major repolarizing currents in the heart. Yet, the signaling mechanisms for norepinephrine- and angiotensin II-induced modulation of I Ks...

...Gehan H. Heeba Background/Aims: This study investigates the ameliorative effect of concurrent and pretreatment with angiotensin II receptor blocker, losartan (LOS), against gentamicin (GEN)-induced renal damage . Methods: Rats were divided into five groups: control, LOS group (10 mg/kg/day for 7...

... including cardioprotective properties. However, its mechanisms of action are not completely understood. The aims of this study were to examine whether nicorandil may alter angiotensin-II (Ang II)-induced cell proliferation and to identify the putative underlying signaling pathways in rat cardiac fibroblasts...

...-1), angiotensin II (Ang II) and bradykinin (BK). These vaso-active peptides play a fundamental role in controlling the functional and structural integrity of the arterial wall and may be important in physiological processes and in pathological mechanisms underlying vascular diseases. In the rat...

... Asada V. Satya Prasadb aDepartment of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, and bDepartment of Anatomy, MNR Medical College, Sangareddy, India Key Words Angiotensin II AT1 receptor antagonist Duodenal ulcer Gastric cytoprotection Gastric secretion Gastric ulcer Losartan...

...Melvin J. Fregly; Margarethe Brummermann Chronic exposure of rats to cold (5°C, 3-4 weeks) results in the development of hypertension. To assess potential mechanisms by which this may occur, the vascular responsiveness to administration of phenylephrine (an α-adrenergic agonist) and angiotensin II...

...Nambi Aiyar; Elayne Griffin; Richard Edwards; Joseph Weinstock; James Samanen; Formal Nambi Angiotensin-II (AII) receptors have been classified as AT 1 and AT 2 subtypes based on selective antagonists. AII binding sites in bovine ovary membranes were characterized using the radiolabeled AII...

... by radioimmunoassay. The most potent inhibitors were pinacidil, capsaicin, glyburide, and quinine. These reagents were more potent against aldosterone production than against cortisol production. Aldosterone produced under basal conditions, as well as that stimulated by potassium, angiotensin II, or dibutyryl cyclic...

... in water intake which was abolished by peripheral pretreatment with naloxone (1 mg/kg, s.c). Previous studies have suggested that the dipsogenic response to isoproterenol is mediated through angiotensin II. In the present study the angiotensin II-induced (200 µg/ kg, s.c.) dipsogenic response was abolished...

...J.T.A. Knape; P.A. van Zwieten The influence of changes in the sodium balance on angiotensin II induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II...

...-dependent fashion. Similar doses of ADH applied to the serosal side did not produce a significant effect. Angiotensin II (Agt II, serosal side) and amphotericin B (mucosal side) reversed the depressor effect of mucosal ADH. The effect of ADH was less when the Cl∼ serosa to mucosa movement was blocked...

...Neil P. Lewis; Douglas R. Ferguson 3 H-Angiotensin II binding was studied in rat renal proximal tubular basolateral membranes. The characteristics of binding were found to be consistent with a receptor for angiotensin II at this site. Effects of angiotensin II on cAMP production were studied...

...İclal Çakıcı; Hakan Zengil; Nurettin Abacıoğlu; İlker Kanzık The effect of angiotensin II (A II) on isolated rat anococcygeus muscle was investigated. A II, when used submaximally (4 × 10 –9 mol/l), produced a rapid contraction of the rat anococcygeus muscle. However, a profound tachyphylaxis...

... (NT) was ineffective and angiotensin II (AII) produced inhibition. On the portal vein of the rat, CER and CCK-8 were ineffective, whereas stimulation occurred with SP (5.72), NT (6.79), AII (7.89), and carbachol (5.50). Tetrodotoxin did not modify these effects in both types of preparation. Cyclic...

.... Neither the angiotensin II receptor antagonist, saralasin nor an arginine vasopressin antagonist (AVP-A) modify the BAY k 8644 induced pressor response. Thus, BAY k 8644 appears to directly increase MABP in the rat by activation of calcium influx into vascular smooth muscle and/or cardiac muscle cells...

...Z.S. Ercan; F.F. Ersoy; T.A. Bökesoy; R.K. Türker Histamine H 1 -receptor antagonist mepyramine and H 2 -receptor antagonist metiamide, respectively diminished and potentiated angiotensin II (AII)-induced myotropic responses in the rabbit aortic strips. The responses of the octapeptide were also...

... administration of DOC did not prevent the drinking response to acute intraperitoneal administration of angiotensin II (200 μg/kg body weight). In contrast, the drinking response was enhanced compared with that of control rats given angiotensin II acutely. While attenuation of the drinking response...

...Therezinha B. Paiva; Maria E. Miyamoto; A.C.M. Paiva An alkylating analogue of angiotensin II (AII) containing a nitrogen mustard group (p-[N, N-bis(2-chloroethyl) aminojphenylbutyryl at the N-terminus ([Chi 1 ]-All) was shown to be an irreversible specific inhibitor of the action of AII...