... by greatly enhancing relaxations in wild-type mice, while having no effect in Gper -/- mice. Contractions to angiotensin II and phenylephrine in wild-type mice were partly sensitive to gp91ds-tat but unaffected by aging. Again, deletion of GPER abolished effects of Nox inhibition on contractile responses...

... the progression of renal dysfunction through its cytotoxicity and proinflammatory effects such as the induction of intercellular adhesion molecule (ICAM)-1 expression in vascular endothelial cells (ECs). Olmesartan, one of the angiotensin II type 1 receptor blockers (ARBs), has been reported to show protective...

...Aline C.O. Costa; Lenice K. Becker; Éder R. Moraes; Thiago R.L. Romero; Luciana Guzzo; Robson A.S. Santos; Igor D.G. Duarte The G protein-coupled receptor Mas was recently described as an angiotensin-(1–7) [Ang-(1–7)] receptor. In the present study, we demonstrate an antinociceptive effect of Ang...

...Chi-shing Sum; Wing-tai Cheung Angiotensin had a dual action on the epididymal half of rat vas deferens. It potentiated electrical stimulated contraction and exerted a direct contractile effect on the muscle. The potentiation of electrically stimulated response may be mediated by presynaptic...

... rats, elevated blood pressure induced 5 weeks previously returned to normotensive levels. Pressor responsiveness to angiotensin, vasopressin and norepinephrine in unanesthetized rats was studied after prevention of hypertension in control, low-renal-mass hypertensive (LRM) and low-renal-mass...

...Noureddine Rouissi; Francois Nantel; Guiy Drapeau; Nour-Eddine Rhaleb; Stéphane Dion; Domenico Regoli Neurokinins, bradykinin and angiotensins were tested in isolated urinary bladder of the guinea pig, the hamster and the rat, in the absence and in presence of a variety of peptidase inhibitors...

... the effects of substance P, neurokinins, bradykinin and inhibited angiotensin I in two preparations, the dog carotid artery, the rat portal vein, and, excluding bradykinin, also in the rabbit pulmonary artery. Captopril and thiorphan significantly potentiated the maximal response of the rat portal vein...

...Heiko Iven; Gerhard Zetler Angiotensin, bradykinin, substance P, physalaemin, and Met-enkephalin were tested for their ability to affect the action potential (AP) of the isolated guinea pig papillary muscle driven at 1/sec and 3/sec. Variables studied were height and duration of AP, dV/dt max half...

...Joan M. Kapsha; Lanny C. Keil; Patricia A. Klase; Walter B. Severs Angiotensin, present in the central nervous system and kidneys, affects salt/water balance when administered to either site but the relationship between central and peripheral actions is unclear. One reported difference between...

... are essential for this effect. Pressor responses to norepinephrine or angiotensin were unaffected even after 20 weeks of pretreatment but those to electrical stimulation of the posterior hypothalamus were increased in rats pretreated with Enovid. Enhanced responsiveness to hypothalamic stimulation occurred only...

... reactivity of norepinephrine and angiotensin is not significantly changed by hydrocortisone during hemorrhagic shock. A metabolic rather than hemodynamic action seems to be involved in the protective role of hydrocortisone in hemorrhagic shock. 22 09 1972 28 5 2008 © 1973 S. Karger AG, Basel...

...L. Volicer; Charlotte G. Loew Light surgical anesthesia by urethane, but not by chloralose or pentobarbital, inhibited the rise of blood pressure and compensatory bradycardia caused by single injections of angiotensin. Urethane also diminished the pressor effect of angiotensin infusion even when...

...H. Karppanen; H. Vapaatalo; Salme Lahovaara; M.K. Paasonen Pharmacology 3: 76-84 (1970) Pinealeclomy Hypertension, experimental Angiotensin Renin activity Pressor responses Monoamines Electrolytes Studies w ith Pinealectomized R ats1 H. Karppanen. H. Vapaatalo, Salme Lahovaara and M. K. P aasonen...

...Seiichiro Kano; Kumi Satoh; Shigeru Kaneta; Kazuo Ichihara Olmesartan is a selective angiotensin II type 1 receptor (AT 1 ) antagonist. In pentobarbital-anesthetized open-chest dogs, ischemia/reperfusion was induced by ligating the left anterior descending coronary artery for 20 min and releasing...

...James Ziogas; Kirstan Vessey The aims of the present study were to determine the angiotensin II (AngII) receptor subtype(s) involved in vasoconstriction and enhancement of sympathetic neurotransmission in rat isolated mesenteric arteries. Vasoconstriction was assessed in mesenteric artery ring...