...Tugba Gulsun; Buket Ucar; Selma Sahin; Christian Humpel Introduction: Alzheimer’s disease (AD) is a severe neurodegenerative disorder of the brain characterized by degeneration of cholinergic neurons which is directly linked to cognitive decline. Nerve growth factor (NGF) is the most potent...

...Zhonglei Bao; Huixue Zhang; Hong Jiao; Xiaojie Chu; Jin Fu; Lihua Wang Introduction: The plaques formed by amyloid-β (Aβ) accumulation and neurofibrillary tangles formed by hyper-phosphorylated tau protein are the 2 major pathologies of Alzheimer’s disease (AD). Recently, autophagy is considered...

...Hande Karahan; Sevda Lüle; Pelin Kelicen-Uğur Background/Aims: Decreasing levels of aromatase and seladin-1 could be one of the molecular mechanisms of Alzheimer’s disease (AD). Aromatase is an enzyme that catalyzes estrogen biosynthesis from androgen precursors, and seladin-1 is an enzyme...

...Bianca Hutter-Schmid; Christian Humpel Alzheimer's disease (AD) is a severe neurodegenerative disorder of the brain, characterized by extracellular beta-amyloid (Aβ) plaques, intracellular tau pathology, neurodegeneration and inflammation. There is clear evidence that the blood-brain barrier...

...Yujie Cheng; Zhi Dong; Sha Liu Background/Aims: The activation of cannabinoid receptor 2 (CB2) has the beneficial effect of reducing neuroinflammatory response in the treatment of Alzheimer's disease (AD) and is suggested to trigger the peroxisome proliferator-activated receptor-γ (PPARγ) pathway...

.... Acetylcholine receptor Muscarinic receptor Memory Alzheimer’s disease Schizophrenia Muscarinic acetylcholine (ACh) receptors (mAChRs) have long been associated with memory processes [ 1 ]. Yet an unanswered question is how each of the 5 mAChR subtypes influences memory, a question that has important...

... treatment with the cholinesterase inhibitor donepezil for 1 year. Her only other regular medications were topical glaucoma preparations. We suggest that mental stress, mild cognitive impairment and Alzheimer’s disease pathology combined to generate SAA in this patient. We also consider that SAA may have...

.... Alzheimer’s disease Parkinson’s disease Huntington’s disease Spinocerebellar ataxia Multiple systemic atrophy Niemann-Pick disease Progressive supranuclear palsy Amyotrophic lateral sclerosis Prions Amyloid proteins Cholesterol Mitochondria Review Pharmacology 2010;85:1 17 DOI: 10.1159/000259044...

...-Amino-1,2,3,4- tetrahydroacridine Tacrine® Muscarinic receptor Cholinesterase inhibitor Alzheimer’s disease Memory enhancer Second messengers Signal transduction Original Paper Pharmacology 1993;47:98-110 Jennifers. Kiefer-Day El-Sayed A.M. Abdallah Carlos Forray Norman H. Lee Ok Nyu Kim Esam...

...: Tacrine, a drug with therapeutic potential for dementia: Post-mortem biochemi­ cal evidence. Can J Neurol Sci 1989: 16:504-510. 11 Kumar V. Becker RE: Clinical phar­ macology of letrahydroaminoacridine: A possible therapeutic agent for Alzheimer's disease. Int J Clin Pharmacol Ther Toxicol 1989:27: 478...

... in an intact astroglial network, which might be of importance in neurodegenerative diseases, such as Alzheimer’s disease. 10 04 2007 17 04 2007 2 8 2007 © 2007 S. Karger AG, Basel 2007 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...

...A. Kumar; P.S. Naidu; N. Seghal; S.S.V. Padi Alzheimer’s disease is a complex and multifactorial neurodegenerative disease. Central administration of colchicine, a microtubule-disrupting agent, causes loss of cholinergic neurons and cognitive dysfunction that is associated with excessive free...

...Laurent Lecanu; Yao Wenguo; Jing Xu; Janet Greeson; Vassilios Papadopoulos Alzheimer’s disease (AD) is the most common dementia occurring in elderly. We report herein the neuroprotective properties of procaine and other anesthetic agents against β-amyloid-induced neurotoxicity. Procaine displayed...

...Imrich Blasko; Thomas Bodner; Gabriele Knaus; Thomas Walch; Andreas Monsch; Hartmann Hinterhuber; Josef Marksteiner In a pilot study designed as a case control study the efficacy of donepezil treatment was investigated in patients with Alzheimer’s disease (AD). Patients were stratified according...

.... Choline Muscarinic acetylcholine receptors M 1 subtype Neuronal nitric oxide synthase Calcium signaling Alzheimer’s disease Original Paper Pharmacology 2000;60:82 89 Received: March 1, 1999 Accepted: June 15, 1999 Choline Is a Full Agonist in Inducing Activation of Neuronal Nitric Oxide Synthase...