...Ji Huang; Chang Liu; Xiu-Fen Ming; Zhihong Yang Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose...

...Bilgen Basgut; Melissa A. Whidden; Nataliya Kirichenko; Mary Woods; Benedek Erdos; Philip J. Scarpace; Nihal Tümer Aim: The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by regulatory central...

...Katsuo Koike; Mitsutoshi Satoh; Saburo Kanai; Hiroshi Ohtsuki; Issei Takayanagi To study the effects of aging on the blood pressure potency of phenylephrine, 6-, 10- and 40-week-old rats were used. In anesthetized rats, the potency (pD 2 value) of phenylephrine on the blood pressure tended...

...Jane E. Smith; Joan M. Lakoski The pharmacological effects of the dual serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine reuptake inhibitor, duloxetine, on serotonergic function in the aging hippocampus were studied using an in vivo chloral hydrate-anesthetized preparation in the female...

... by lipid-soluble β-blockers may be one of the causes of the fatigue observed in some patients receiving these drugs. 23 11 1992 1 02 1993 10 6 2008 © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...

...S.A. Cohen; W.E. Mutter Subchronic treatment of aged mice with piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl- D -aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor. Since deficits at the level of the NMDA receptor...

... and chronic defeat stress in male mice aged 6 weeks, 7 months and 1 year. Specific uptake in 6-week-old mice was increased from control values only in the cerebellum following acute but not chronic stress. Specific uptake in the cortex and hypothalamus was unchanged from control values following both acute...

... residence time (MRT) and the apparent steady state volume of distribution (V ss ) for the older rats were higher than for the younger ones, but for 5 mg/kg dose the values did not differ. The enhanced responses to morphine in older age group of rats for 5 mg/kg dose cannot be explained solely on the basis...

... subtypes may be necessary for the full expression of behavioral events mediated by the D2 receptors. Dopamine receptors Calcium channel blocker Autoradiography, in vitro Aging © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

...Mark E. Olah; Ralf G. Rahwan This study was undertaken to determine the relative age-dependent responsiveness of the rat aorta to depolarizing (potassium) and receptor-activating (norepinephrine) contractile stimulants, and to the calcium antagonists propyl-methylenedioxyindene (pr-MDI...

...Gamal Shams; Lane J. Wallace; Duane D. Miller; Dennis R. Feller Thromboxane A 2 (TXA 2 ) is a bioactive metabolite of arachidonic acid which produces vascular smooth muscle contraction and blood platelet aggregation. The goal of this study is to establish whether there are age-dependent differences...

...Raymond E. Galinsky; George B. Corcoran The effects of aging on acetaminophen metabolism and elimination in male Fischer 344 rats were examined after intravenous injection of 300 mg/kg. Age as a variable had only a small effect on the total clearance of acetaminophen. However, the fraction...

... a concentration-related decrease in pigment content. Hydergine also stimulated neurite formation in cells in regular pH medium and was slightly toxic to cells in low pH medium. These results support the use of neuroblastoma cells as an in vitro model for age pigment studies. 29 5 2008 © 1978 S. Karger...

... 2006 S. Karger AG, Basel 2006 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying...

... administered flavonoids (apigenin-7-glucoside and quercetin) on the cognitive performance in aged and LPS-treated mice (an animal model for AD) using passive avoidance and elevated plus-maze tasks. Aged and LPS-treated mice showed poor retention of memory in step-through passive avoidance and in plus-maze...

...B.A. Olson; J.R. Day; N.J. Laping Age-related increases occurred in renal thrombospondin 1 (TSP1) mRNA in F344 rats, resembling diabetes-induced TSP1 mRNA in the obese Zucker rat. TSP1 mRNA was 3.5-fold higher in 24-month-old than in 3-month-old F344 rats. TSP1 mRNA increased similarly in 5-month...

...A.M. de Oliveira; C. Campos-Mello; M.C. Leitão; F.M.A. Correa Functional correlates of α 1 -adrenoceptors were studied in thoracic aorta and carotid arteries from Wistar rats, at maturation (3- and 8-week-old) and aging (17- and 29-week-old) phases, using phenylephrine (PHE) and KCl. PHE and KCl...