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Keywords: Aging
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2020) 105 (9-10): 491–504.
Published Online: 26 May 2020
...Ji Huang; Chang Liu; Xiu-Fen Ming; Zhihong Yang Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 100 (3-4): 105–114.
Published Online: 19 May 2017
...Bilgen Basgut; Melissa A. Whidden; Nataliya Kirichenko; Mary Woods; Benedek Erdos; Philip J. Scarpace; Nihal Tümer Aim: The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by regulatory central...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (4): 217–222.
Published Online: 10 June 2008
...S.A. Cohen; W.E. Mutter Subchronic treatment of aged mice with piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl- D -aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor. Since deficits at the level of the NMDA receptor...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (5): 295–299.
Published Online: 10 June 2008
... College, New York, N.Y., USA Lipophilic Beta-Blockers Inhibit Rat Skeletal Muscle Mitochondrial Respiration Key Words ß-Blockers Skeletal muscle Mitochondria Respiration Aging Fatigue Abstract Propranolol, metoprolol, acebutolol, nadolol and atenolol were incubated with isolated rat skeletal muscle...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 43 (5): 256–263.
Published Online: 06 June 2008
... residence time (MRT) and the apparent steady state volume of distribution (V ss ) for the older rats were higher than for the younger ones, but for 5 mg/kg dose the values did not differ. The enhanced responses to morphine in older age group of rats for 5 mg/kg dose cannot be explained solely on the basis...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 46 (1): 9–12.
Published Online: 06 June 2008
... subtypes may be necessary for the full expression of behavioral events mediated by the D2 receptors. 11 02 1991 12 02 1992 6 6 2008 Dopamine receptors Calcium channel blocker Autoradiography, in vitro Aging © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 42 (4): 181–187.
Published Online: 06 June 2008
... and chronic defeat stress in male mice aged 6 weeks, 7 months and 1 year. Specific uptake in 6-week-old mice was increased from control values only in the cerebellum following acute but not chronic stress. Specific uptake in the cortex and hypothalamus was unchanged from control values following both acute...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1990) 40 (1): 27–32.
Published Online: 05 June 2008
...Gamal Shams; Lane J. Wallace; Duane D. Miller; Dennis R. Feller Thromboxane A 2 (TXA 2 ) is a bioactive metabolite of arachidonic acid which produces vascular smooth muscle contraction and blood platelet aggregation. The goal of this study is to establish whether there are age-dependent differences...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1986) 32 (6): 313–320.
Published Online: 04 June 2008
...Raymond E. Galinsky; George B. Corcoran The effects of aging on acetaminophen metabolism and elimination in male Fischer 344 rats were examined after intravenous injection of 300 mg/kg. Age as a variable had only a small effect on the total clearance of acetaminophen. However, the fraction...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1978) 16 (Suppl. 1): 88–92.
Published Online: 29 May 2008
... a concentration-related decrease in pigment content. Hydergine also stimulated neurite formation in cells in regular pH medium and was slightly toxic to cells in low pH medium. These results support the use of neuroblastoma cells as an in vitro model for age pigment studies. Aging Hydergine In culture...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2006) 78 (4): 198–201.
Published Online: 30 November 2006
... 2006 S. Karger AG, Basel 2006 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2003) 69 (2): 59–67.
Published Online: 03 September 2003
... administered flavonoids (apigenin-7-glucoside and quercetin) on the cognitive performance in aged and LPS-treated mice (an animal model for AD) using passive avoidance and elevated plus-maze tasks. Aged and LPS-treated mice showed poor retention of memory in step-through passive avoidance and in plus-maze...
Journal Articles
Journal Articles