... CYP2D6 CYP2E1 CYP3A3/4 Metabolism, in vitro Phenacetin Acetaminophen Phenytoin S-Mephenytoin Dextromethorphan Dextrorphan Chlorzoxazone Alprazolam Immunoinhibition Monoclonal antibody Polyclonal antibody © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright...

... pressure (PP), hot plate (HP) and tail flick (TF) tests. Each drug was injected intraperitoneally 24 and 12 h before ET injection and just before each pain test at 3, 6, 9 and 24 h after ET injection. At the dosages used, acetaminophen and dexamethasone were the most effective in reducing PP hyperalgesia...

...Kentaro Nakamoto; Yoshinori Kamisaki; Kouichirou Wada; Hironaka Kawasaki; Tadao Itoh We examined the effect of acetaminophen, an analgesic and antipyretic drug, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Ischemia-reperfusion was induced by clamping the celiac artery...

...Larry R. Engelking; Jeanne Lofstedt; Gershwin T. Blyden; David J. Greenblatt The following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug...

...Joseph M. Scavone; David J. Greenblatt; Barbara W. LeDuc; Gershwin T. Blyden; Becki G. Luna; Jerold S. Harmatz The effect of cigarette smoking on drug oxidation and conjugation was studied using antipyrine and acetaminophen as marker compounds. For the antipyrine study, healthy cigarette smokers (n...

...Raymond E. Galinsky; George B. Corcoran The effects of aging on acetaminophen metabolism and elimination in male Fischer 344 rats were examined after intravenous injection of 300 mg/kg. Age as a variable had only a small effect on the total clearance of acetaminophen. However, the fraction...

...C.-P. Siegers; C.D. Klaassen Over one fourth (28.4%) of a 100 mg/kg intravenous dose of acetaminophen (AA) is excreted into bile of conscious rats within 8 h. The main metabolite in bile was the glucuronide (14.3%), followed by the sulfate (8.2%), the glutathione conjugate (4.7%) and unchanged AA...

...H.E. Poulsen; A. Lerche; N.T. Pedersen Rats were pretreated with phenobarbital to induce hepatic cytochrome P-450. Compared to noninduced rats, a similar relation between the dose of acetaminophen and mortality, and between dose and changes in liver function (prothrombin index) and identical time...

...Hermann R. Ochs; David J. Greenblatt; Birgitt Verburg-Ochs; Darrell R. Abernethy; Martin Knüchel Factors influencing hepatic oxidation of antipyrine and conjugation of acetaminophen were evaluated in volunteers who received 1.0 g of antipyrine intravenously and on a different occasion a 650 mg...

...Craig Schnell; Haig P. Bozigian; Marc H. Davies; Alex Merrick; Kyung S. Park; D.A. McMillan Experiments were conducted to examine the effects of changes in lighting schedules and food consumption on circadian rhythms in acetaminophen lethality and hepatic glutathione levels in male mice. Under...

...D.J. Jollow; S.S. Thorgeirsson; W.Z. Potter; M. Hashimoto; J.R. Mitchell The relationship between the metabolic disposition of acetaminophen and the susceptibility of hamsters, mice and rats to acetaminophen-induced liver necrosis has been examined. The fraction of low doses of acetaminophen...

...W.Z. Potter; S.S. Thorgeirsson; D.J. Jollow; J.R. Mitchell We previously postulated that acetaminophen-induced hepatic necrosis in mice results from the formation of a reactive metabolite that arylates vital cellular macro-molecules. While studying species differences in susceptibility...

...Bobby D. Nossaman; Syed R. Baber; Mohammed M. Nazim; Paul R. Waldron; Albert L. Hyman; Philip J. Kadowitz In contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), the nonopioid analgesics phenacetin, acetaminophen and dipyrone exhibit weak anti-inflammatory properties. An explanation...

... Children s Research Hospital, Memphis, Tenn., USA Key Words Acetaminophen Thalassemia Drug metabolism UDP-glucuronosyltransferases (p ! 0.05). Our study suggests that a subtherapeutic level of PCM may occur in patients who have UGT1A6*2 without UGT1A1*28. Copyright © 2007 S. Karger AG, Basel Abstract...

... or should not be avoided in patients undergoing liver resection. 17 04 2006 23 05 2006 1 9 2006 Acetaminophen Metabolism Liver resection Original Paper Pharmacology 2006;77:161 165 DOI: 10.1159/000094459 Received: April 17, 2006 Accepted: May 23, 2006 Published online: July 10...

...Min-Soo Kwon; Eon-Jeong Shim; Young-Jun Seo; Seong-Soo Choi; Jin-Young Lee; Han-Kyu Lee; Hong-Won Suh Aspirin (ASA) is a widely used oral analgesic which acts as an inhibitor of cyclooxygenase. Acetaminophen (ACET) is also an effective analgesic and may selectively inhibit brain prostaglandin...

...Zhenyuan Song; Craig J. McClain; Theresa Chen An overdose of acetaminophen (APAP) is the most frequent cause of fulminant liver failure in the United States. Increasing evidence demonstrates that oxidative stress plays an important etiologic role in APAP-induced liver injury. S-Adenosylmethionine...