...) and antagonized by the Ml receptor antagonist pirenzepine (100 nmol/l) and telenzepine (100 nmol/l), but not by the M2 receptor antagonist AF-DX 116 (1 μmol/l). Slow excitatory postsynaptic potentials recorded from curarized rabbit isolated superior cervical ganglia were also blocked by telenzepine (300 nmol/l...

... at this position. Affinities of AF-DX 116 and 4-DAMP, as well as the allosteric potency of UH-AH 37, were not sensitive to the M 2 401 ala ⇒ thr mutation. Receptors, muscarinic Mutagenesis Amino acid sequence Threonine UH-AH 37 Pirenzepine AF-DX 116 4-DAMP 14 8 2000 © 2000 S. Karger AG...