...Takuji Machida; Akari Inotani; Saki Shiga; Shuto Kon; Takumi Yanada; Hiroya Kobayashi; Naoya Hamaue; Masahiko Hirafuji; Kenji Iizuka This study aimed to investigate whether the consecutive administration of methotrexate affects 5-hydroxytryptamine (5-HT) synthesis in the rat small intestine. Rats...

...-contractile effect could be due to changes in calcium mobilization. PVAT exerted anti-contractile effect against 5-hydroxytryptamine (5-HT)-induced contractions of aorta segments from pregnant and non-pregnant rats and this anti-contractile effect was attenuated in segments from pregnant rats. Nifedipine (10...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Long-term experimental diabetes 5-Hydroxytryptamine Prejunctional sympathetic inhibition Nitric oxide Eicosanoids...

...S. Batista Lobo; M. Denyer; S. Britland; F.A. Javid The relevance of age on serotonergic involvement in the control of alimentary contractility has not been pharmacologically described. Experiments were performed to investigate the effects of acetylcholine, atropine, 5-hydroxytryptamine (5-HT...

...C.H. Cho; M.W.L. Koo; J.K.S. Ko The involvement of 5-hydroxytryptamine (5-HT) in gastric function and mucosal damage has been defined. 5-HT also potentiates lesion formation in animals. The current study investigated further whether these actions are mediated through 5-HT3 receptors in rats...

... by 50% (v/v) ethanol. Results were compared with those for 5-hydroxytryptamine (5-HT: 10 mg kg –1 )- The possible involvements of gastric mucus secretion, endogenous prostaglandins (PGs) and sulfhydryl compounds (SH) in the protection mediated by CNT were also examined. Intraperitoneal administration...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 5-Hydroxytryptamine 5...

... was dependent on the rate of lung perfusion and the duration of infusion of 5-HTP, and was a saturable process with an apparent K m of 1.8 m M and V max of 0.14 μmol/g/3 min. The indoles found in the lung were 5-HTP, 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA); only 5-HIAA was detected...

...Henry Müller; Erika Glusa; Fritz Markwardt Dihydroergotamine (DHE), administered intravenously to pithed normotensive rats, increased the mean arterial blood pressure dose-dependently. This pressor effect was noncompetitively inhibited by the 5-hydroxytryptamine (5-HT) receptor antagonists...

...Erika Glusa; Fritz Markwardt 5-Hydroxytryptamine (5-HT) caused concentration-dependent contractions in human postmortem femoral venous and arterial strips. In veins, it was a more potent agonist than noradrenaline, while the reverse was true for arteries. Pizotifen and methysergide were competitive...

...-Hydroxytryptamine and Anoxia John A. Barrett. Vincent DePaitl Lynch+, Joseph Balkon. Ronald D. Smith. Peter S. II oil' Department of Pharmaceutical Sciences, St. John's University, Jamaica. N.Y., USA Key Words. 5-Hydroxytryptamine Diltiazem Verapamil Nifedipine Nitroglycerin Dipyridamole Coronary arterial...

... of the artery are responsive to norepinephrine (NE), 5-hydroxytryptamine (5HT) and vasopressin (VP) at low concentrations, but at the maximal frequency of transmural electrical stimulation used (16 Hz), the response is only 10–20% of the NE maximum response. Phentolamine (2.7 x 10 –6 M ) antagonized responses...

...Roger Drew; Zahid H. Siddik Rat lung slices were used to examine the effects of citalopram, a compound reported to be a specific inhibitor of neuronal uptake of 5-hydroxytryptamine (5HT), on the pulmonary accumulation of 5HT, noradrenaline (NA), imipramine (IP) and paraquat (PQ). 5 x 10 –9 mol/l...

.... These data suggest that indomethacin at 1 µg/ml inhibits endogenous synthesis of vasoconstrictive prostaglandin-like substances whereas indomethacin at higher concentrations causes nonspecific relaxation. Contractions induced by 5-hydroxytryptamine (5-HT), KC1 and prostaglandin F 2α (PGF 2α ) were...

... to in the content or advertisements. Amphetamine Catecholamines p -Chloroamphetamine Fenfluramine 5-Hydroxytryptamine Hyperthermia Pharmacology 13: 163-176 (1975) Hyperthermia Induced by Amphetamine, p-Chloroamphetamine and Fenfluramine in the R at1 -H. Frey Department of Pharmacology and Toxicology...

...J.H. Yu; C.B. Smith Uptake and metabolism of 3 H-5-hydroxytryptamine ( 3 H-5-HT) in slices of hypothalamus, brain stem, caudate nucleus and parietal cortex were examined in vitro . The results indicate that 3 H-5-HT taken up by neurons is firmly retained and that there are regional differences...

...L.F. de Oliveira; A.D. Bretas; L. Sollero Morphine has been shown to release 5-hydroxytryptamine (5-HT) from the intestinal wall of dogs. The 5-HT released is suspected to be the mediator of the contractile effect of the narcotic-analgesics in the intestine, probably by acting upon post-ganglionic...

..., and a combination of phentolamine with methysergide or promethazine. As opposed to this, the increase in pulmonary pressure induced by noradrenalin, adrenalin, tyramine, 5-hydroxytryptamine or histamine can be blocked by phentolamine, methysergide, or promethazine. Phentolamine prevents the effect of aminorex...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 5-Hydroxytryptamine Liver circulation Necrosis Light and electron microscopy Pharmacology 3: 321 329 (1970) o-ilydroxytryplamine Liver circulation Necrosis Light and electron...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Terminal part of guinea-pig ileum Supersensitivily Cocaine Catecholamine 5-Hydroxytryptamine Reserpine Pharmacology 3: 282-290 (1970) Terminal part of guinea-pig...