... as neurogenic twitches or relaxations were registered. In the rat stomach strip EC 50 of acetylcholine, serotonin (5-HT) and KC1 was estimated. MDP (50 nmol/l) but not levamisole potentiated selectively the contractions evoked by 5-HT and significantly (p < 0.01) lowered the respective EC50. In the rat vas...

...L.F. de Oliveira; L. Sollero The effects of intra-arterially (i.a.) injected morphine and dextromoramide on 5-hydroxytryptamine (5-HT)-induced contrac tion of the jejunum of dog were tested. Dextromoramide increased the intestinal contractile action of 5-HT from 44.7 ± 8.8 cm H 2 ·to 154.6 ± 17.3...

...B. Živković; M. Bulat After i.v. or spinal subarachnoid application of 5-hydroxytryptamine (5-HT) in cat an increase of 5-HT, followed by augmentation of 5-hydroxyindoleacetic acid (5-HIAA), in the spinal cordis observed. Concomitantly, 5-HIAA increases in the perfusate of spinal subarachnoid space...

...H. Liu; H.R. Irving; Y.Y. Tan; L. Meng; N. Chetty; I.M. Coupar The aim of this study was to obtain more information regarding the ‘atypical’ 5-HT 7 receptor of the rat jejunum. 5-HT 7 -induced contractions of the jejunum were elicited by 5-HT in the presence of ondansetron. Maximal responses were...

...Haihuang Liu; Ian M. Coupar; Helen R. Irving The rat isolated jejunum was used as a functional model to screen some antidepressant drugs at the ‘atypical’ 5-HT 7 receptor. Mianserin acted as a surmountable antagonist of 5-CT with a p A 2 value of 8.22 ± 0.33. The apparent p K B of maprotiline...

... the inhibition of gastric emptying caused by pyrogallol 100 mg/kg. Ondansetron (3 mg/kg, p.o.) significantly reversed the pyrogallol effect. The effect of pyrogallol on malondialdehyde (MDA) levels and 5-HT levels in the stomach tissue was also studied. Pyrogallol at a dose of 100 mg/kg, i.p., significantly...