The article entitled “Regulation of iRhom-2/Tumor Necrosis Factor-α Converting Enzyme Pathway and Oxidative Stress Protects the Renal Injury with Anemonin in Streptozotocin-Induced Diabetic Nephropathy Neonatal Rat Model” [Pharmacology. 2019;104(5–6):258–66; DOI: 10.1159/000501631] by Lingyan Qiao, Yusheng Liu, Cheng Li, Juan Ge and Tang Li has been retracted by the Publisher and the Editor.

After the publication of this article, concerns were raised about the integrity of some of the data presented. Specifically, in Figure 5b the representative image for the Anemonin 75 mg/kg group was found to be partially duplicated in the representative image for the DN group in the same figure. A duplication between Figure 5a of this article and Figure 2a of a previously published article by a different author group was also found [1]. In addition, the images representing the TACE and β-Actin Western blots in Figure 4 of this article were found to be the same as the Western blots represented in Figure 5 of a previously published article by a different author group [2].

The authors did not respond to requests to comment on the concerns within the given timeframe despite multiple attempts of contact. The matter has been raised to the corresponding author’s institution who did not respond to our request for an investigation. Given the severity of the concerns raised this article is being retracted. The authors have not responded to our correspondence regarding this retraction despite multiple attempts of contact.

Huang G, Lv J, Li T, Huai G, Li X, Xiang S, Wang L, Qin Z, Pang J, Zou B, Wang Y. Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway. Int J Mol Med. 2016;38(4):1179–89. DOI: 10.3892/ijmm.2016.2713.
Ding Z, Shi H, Yang W. Osteoprotective Effect of Cimiracemate in Glucocorticoid-Induced Osteoporosis by Osteoprotegerin/Receptor Activator of Nuclear Factor κ B/Receptor Activator of Nuclear Factor Kappa-Β Ligand Signaling. Pharmacology. 2019;103(3–4):163–72. DOI: 10.1159/000495509.