Abstract
Drug-induced lung disease (DILD) is a common but frequently missed diagnosis. Therefore, a high index of clinical suspicion and familiarity with the clinical syndromes associated with DILD are important in making the diagnosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the mostly commonly used classes of medications. NSAIDs are safe when used at prescribed doses. Side effects from use of NSAIDs are not uncommon and can affect almost every organ system in the body. NSAIDs are notorious for causing pulmonary toxicity, the common ones being bronchospasm and hypersensitivity reactions. Diffuse alveolar hemorrhage (DAH) secondary to NSAIDs is uncommon. Here, we report a case of DAH secondary to the use of ketorolac tromethamine.
References
1.
Newsome BR, Morales JE: Diffuse alveolar hemorrhage. South Med J 2011;104:269-274.
2.
Lara AR, Schwarz MI: Diffuse alveolar hemorrhage. Chest 2010;137:1164-1171.
3.
Sternbach G: William Osler: narcotic-induced pulmonary edema. J Emerg Med 1983;1:165-167.
4.
Schreiber J: Drug-induced lung diseases (in German). Dtsch Med Wochenschr 2011;136:631-634.
5.
Bhadra KSBT: Drug-induced lung diseases: a state-of-the-art review. J Respir Dis 2009;30:1-17.
6.
Mizushima T: Molecular mechanism for various pharmacological activities of nsaids. Pharmaceuticals 2010;3:1614-1636.
7.
Huppmann AR, Schwartz AM: Drug-induced lung disease. Pathol Case Rev 2007;12:113-117.
8.
Van Renterghem D, Depuydt C: Hemoptysis and pulmonary edema in a scuba diver using diclofenac. Pharmacology 2012;89:103-104.
9.
Yiannakopoulou EC: Hemoptysis under diclofenac and antiplatelet doses of aspirin. Pharmacology 2011;87:1-4.
10.
Reinhart DI: Minimising the adverse effects of ketorolac. Drug Saf 2000;22:487-497.
11.
Camu F, Lauwers MH, Vanlersberghe C: Side effects of NSAIDs and dosing recommendations for ketorolac. Acta Anaesthesiol Belg 1996;47:143-149.
12.
Rubin AS, Hochhegger B, Irion KL, Marchiori E, Binukrishnan SR, Moreira JS, Zanetti G: Ketorolac tromethamine associated with diffuse pulmonary haemorrhage: high-resolution CT findings. Br J Radiol 2010;83:e158-e160.
© 2013 S. Karger AG, Basel
2013
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.