A neuropharmacological comparison was made between cyclazocine and imipramine in rabbits made tolerant to the initial excitation induced by cyclazocine. Both compounds increased EEG synchrony, raised the voltage required to produce EEG activation, and induced mydriasis without concomitantly inducing depression. In combination, low doses of cyclazocine and imipramine induced a synergistic increase in synchrony and inhibited the EEG activation usually produced by physostigmine and methamphetamine. The results support the hypothesis that some narcotic antagonists exert central effects which are not related to occupation of narcotic receptors, and that such effects may be related to reported clinical antidepressant actions.

Keywords:
Cyclazocine, Imipramine
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© 1973 S. Karger AG, Basel
1973
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