Background/Aims: Using a new animal model of postoperative pain we recently developed, we investigated whether the selective cyclooxygenase-2 (COX-2) inhibitor pare-coxib sodium, and the analgesic tramadol hydrochloride, attenuated mechanical primary hyperalgesia induced by minor surgery on the rat tail. Methods: For surgery, rats were anesthetized with isoflurane, a 20-mm-long incision was made through the skin and fascia of their tails, and the wound was sutured. Immediately after surgery, rats were injected intraperitoneally with parecoxib sodium (10 or 20 mg·kg–1), tramadol hydrochloride (10 mg·kg–1), or sterile saline (0.1 ml·kg–1). Hyperalgesia was assessed by measuring rats’ response latencies to a blunt noxious mechanical stimulus (4 N) applied to their tails. Nociceptive testing was performed before surgery and 90 min after surgery. Results: Hyperalgesia was present in all saline-injected animals within 90 min of surgery. This hyperalgesia was not attenuated by postoperative injection of parecoxib. However, administration of tramadol completely prevented the development of postoperative hyperalgesia. Conclusion: We have shown that the hyperalgesia in our model of postoperative pain is responsive to treatment with the analgesic tramadol, but it is not responsive to the selective COX-2 inhibitor parecoxib at the doses we used.

Keywords:
Surgery, Incision, Analgesia, Antihyperalgesia, Hyperalgesia, primary
This content is only available via PDF.
© 2007 S. Karger AG, Basel
2007
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.