Light surgical anesthesia by urethane, but not by chloralose or pentobarbital, inhibited the rise of blood pressure and compensatory bradycardia caused by single injections of angiotensin. Urethane also diminished the pressor effect of angiotensin infusion even when the increase of the total peripheral resistance was unaffected. Urethane blocked angiotensin induced increase of coronary blood flow and decrease of the duodenal blood flow but it did not change the decrease of the renal blood flow. These results indicate that urethane anesthesia blocks an indirect component of cardiovascular activity of the angiotensin, which makes up about 30% of the total pressor effect of angiotensin.

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