The injection of epinephrine (1.0 mg/kg) into alloxan-diabetic, fasted rats depressed the serum concentration of previously administered α-aminoisobutyric acid (AIB) and 1-aminocyclopentanecarboxylic acid (ACPC) within 2 h and simultaneously increased the concentration of these amino acids in the liver. The increase of ACPC and AIB concentrations in the liver following epinephrine injection was nearly 3 times as great in the alloxan-diabetic rats as in normal intact rats. The levels of the two amino acids in skeletal muscle, heart, and diaphragm of the alloxanized rats were unchanged following epinephrine injection, but the distribution ratios in these tissues were raised because the serum concentration decreased 20%.Further studies were carried out employing rats that were treated 1 h before epinephrine injection, with mannoheptulose, a compound which blocks insulin release. The concentration of ACPC and AIB in the serum 2 h after epinephrine injection were lowered. At the same time the concentrations of ACPC in liver and heart were raised, as was the concentration of AIB in heart. The levels of the two amino acids in skeletal muscle and diaphragm were unaltered. However, distribution ratios were raised in the four tissues. These results demonstrate that epinephrine enhances AIB and ACPC transport into the tissues of the insulin-deficient rats in vivo and suggest that epinephrine-stimulated amino acid transport is not due indirectly to insulin.

Keywords:
Epinephrine, Amino acid uptake, Diabetic rat, Insulin, Alloxan, Mannoheptulose, α-Aminoisobutyric acid, Cycloleucine, 1-Aminocyclopentane-carboxylic acid, Model amino acids
This content is only available via PDF.
© 1971 S. Karger AG, Basel
1971
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.