The effect of ternatin, a tetramethoxyflavone from Egletes viscosa Less., on liver injury induced by carbon tetrachloride (CCI4) was investigated in rats. Twenty-four hours following CCI4 insult (2.5 ml/kg s.c), changes in the serum enzymes, alanine aminotransferase, aspartate aminotransferase and γ-glutamyltransferase, as well as liver cell histology were used as indices of hepatic dysfunction. The results show that ternatin (30 mg/kg i.p daily for 5 consecutive days) causes marked inhibition of CCLl4-induced serum enzymes and morbid histologic changes. The observation suggests that ternatin possesses anti-hepatotoxic activity.

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