The effect of food intake and gut bacterial flora on gastrointestinal lesions caused by oral indometacin (IND) was studied in rats. A dose of 10 mg/kg IND caused no intestinal lesions when the animals were starved before and after treatment; it produced moderate lesions when the animals were continuously fed and maximal lesions when the animals were fed in the postdrug period after starvation in the predrug period. Under germ-free conditions, 15 mg/kg IND induced significantly less intestinal lesions than under specific pathogen-free conditions. The differences in the magnitude of intestinal lesions under the varying feeding and maintenance conditions were not associated with different IND concentrations in the jejunal mucosa. The dose of 10 mg/kg IND produced most gastric lesions when the animals were previously starved for 24 h and subsequently fed, medium lesions in continuously starved animals and only a few lesions in animals fed before and after IND. The disposition of IND from the gastric mucosa did not differ under the different feeding conditions. As the dose of IND is high enough to inhibit prostaglandin synthesis, it was concluded that additional factors are important for the development of gastrointestinal lesions caused by IND. Secondary bile acids in conjunction with IND are important for the development of intestinal lesions, while gastric acid influences the intensity of gastric lesions.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.