Histamine H1-receptor antagonist mepyramine and H2-receptor antagonist metiamide, respectively diminished and potentiated angiotensin II (AII)-induced myotropic responses in the rabbit aortic strips. The responses of the octapeptide were also inhibited in the presence of histidine decarboxylase inhibitor, 2-hydroxy-5-carbomethoxybenzoxyamine and restored when subcontractile quantities of histamine are added to the inhibitor-containing medium. Inhibition of histamine degradation by aminoguanidine potentiates A II’s responses. These results are taken as evidences indicating AII-induced histamine synthesis in the test preparation.

Keywords:
Angiotensin II, Induced histamine, Rabbit aorta
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© 1979 S. Karger AG, Basel
1979
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