The carotid occlusion response (COR) in dogs was inhibited by 50 and 58 % after intracerebroventricular injection of norepinephrine and hydrochloric acid, both at the pH 2.9. After norepinephrine at pH 7, this inhibition was 22 %. The COR inhibition was 24 % with epinephrine solution of pH 2.4 whereas the same solution at pH 7 produced no inhibition. The injection of drugs solved in acid solution, lead to a decrease in the pH of the cerebrospinal fluid. The response to asphyxia was inhibited by 50 % after injection of norepinephrine at pH 2.9, but not after epinephrine at pH 2.4 or hydrochloric acid. Bradycardia was caused by epinephrine in neutral or acid solution, and a decrease of arterial blood pressure was seen after epinephrine or norepinephrine in neutral or acid solution.

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