Morphine has been shown to release 5-hydroxytryptamine (5-HT) from the intestinal wall of dogs. The 5-HT released is suspected to be the mediator of the contractile effect of the narcotic-analgesics in the intestine, probably by acting upon post-ganglionic cells of the myenteric plexus. In this paper it is shown that the depolarizing agents nicotine and DMPP block the contractile response of the dog intestine in vivo, to intra-arterially injected 5-HT, dextromoramide and morphine. Previous treatment by hexamethonium prevented the blocking effect of DMPP and nicotine. These results suggested that the depolarization of the ganglionic cells, rather than the blockade of the cholinergic receptors, is responsible for the blockade of 5-HT and morphine effects by DMPP and nicotine.

Keywords:
Dextromoramide, DMPP, 5-Hydroxytryptamine, Morphine, Nicotine
This content is only available via PDF.
© 1974 S. Karger AG, Basel
1974
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.