The effects of a number of recently developed agents with antiphlogistic properties (meclofenamic acid, niflumic acid, azapropazon, cinnopentazon, alclofenac, bufexamac, ibufenac, ibuprofen, benzydamine, metiazinic acid, fenclozic acid) and of some established antirheumatics (sodium salicylate, salicylaminophenazone, phenylbutazone, oxyphenbutazone, chloroquine, mefenamic acid, flufenamic acid) on the viability and the multiplication, and in part also on the cell volume and the cell volume distribution of Ehrlich ascites tumor cells cultured in vitro were studied. All tested compounds were found to possess cytostatic properties in vitro; the cytostatic effective concentrations of the various agents, however, were quite different. Cytostatic concentrations of some of the drugs caused marked changes of the mean volume and the volume distribution of the cultured cells, whereas in other cases only slight or insignificant changes of these parameters were observed. With regard to the obtained findings it is discussed, whether an inhibition of cell multiplication might be involved in therapeutic as well as unwanted effects of these drugs in vivo.

Keywords:
Anti-inflammatory drugs, Antiphlogistics, Cell multiplication, Cell suspension cultures, Cell volume, Cell volume distribution, Cytocidal effects, Cytostatic effects, Ehrlich ascites tumor cells
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© 1973 S. Karger AG, Basel
1973
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