The daily sodium (Na) and Potassium (K) excretion was measured in conscious rats treated in the following way: on the first day a subcutaneous infusion of isotonic sodium chloride (NaCl) was induced (5 ml = 775 µEq/100 g body weight) and the following days electrolyte losses of the day before were replaced. Na was substituted by subcutaneous perfusion, K by oral loading with isotonic solutionsA daily increase in Na and K excretion was observed. Na excretion was maximal on the seventh day, K excretion on the eighth day.After the maximum urinary excretion Na output decreased slightly, and K excretion remained nearly constant until the eleventh day when the experiment was terminated.Creatinine clearance was parallel to Na excretion.Under the same experimental conditions, rats, from which the superficial parts of the kidney cortex had been bilaterally dissected (about 50 % of the kidney mass), showed a daily increase in K excretion, whereas Na excretion and creatinine clearance remained unchanged from the first until the fourth day.It is concluded that the phenomenon of ‘Na adaptation’ depends on a stepwise redistribution of the filtrate towards the superficial nephrons, and is independent of ‘K adaption’.

Keywords:
Natriuresis, continued, Potassium adaptation, balance, Sodium adaptation, balance
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© 1973 S. Karger AG, Basel
1973
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