Sulpiride was administered to 21 children with school phobia. All had shown some depressive symptoms in addition and had been treated by nonpharmacological measures. 13 of them returned to school within a few days and depressive symptoms disappeared eventually (the recovered group). In 3, behaviour at home returned to their premorbid status, but school refusal persisted (the improved group). In the remaining 5, no improvement was observed. In comparison to the present writer’s previous experience with imipramine and benzodiazepines, the response to sulpiride in school-phobic children is more rapid and remarkable.