... constructed a cell line, ELα4-2, which constitutively expresses the α-4 gene product. The ELα4-2 cells are derived from the rat fibroblast EL2, in which EGF induces a marked c-fos and c-myc proto-oncogene transcription. Here we report that in ELα4-2 cells, the gene expression induced by EGF was negatively...

... produced any metastatic lesions in liver, lung, brain, bone marrow or spleen in athymic nude mice. Northern blot analysis of c-myc mRNA levels in different BL cell lines revealed a possible relationship between percent tumor takes (but not growth rates) and the level of c-myc oncogene expression. However...

...Masahide Ikeguchi; Yasuaki Hirooka Objectives: c -myc is a transcription factor that regulates cell proliferation, differentiation, and apoptosis. However, little is known about the clinical importance of c -myc mRNA expression in a primary hepatocellular carcinoma (HCC). In this study, we...

... after laser-based microdissection by quantitative real-time PCR using the TaqMan ® detection system for amplification of the c -erbB2 , topoisomerase IIα , c -myc and cyclinD1 gene. In a subset of 17 DCIS with adjacent infiltrating tumour components we compared intraductal and invasive tumour components...