... against the mouse transferrin receptor; (2) exposure to the iron chelator deferoxamine (DFO), and (3) exposure to a defined culture medium without any added iron (iron-poor medium). When each antibody was present at a concentration of 5 µg/ml, the number of living cells declined to approximately 25% after...

...Leonard M. Neckers Transferrin receptor expression is vital for the continuous growth of most cells. Although iron plays a key role in modulating transferrin receptor expression, other physiological factors are also capable of affecting receptor expression. In hematopoietic cells, these include...

... to translate subunits. Similar stem-loop motifs occur in the 3’ untranslated region of the transferrin receptor messenger where they regulate breakdown of the receptor mRNA. Finally, the presence of excess iron preferentially stimulates transcription of more ferritin message of one type (L-mRNA) which produces...

...John D. Kemp; Kevin M. Smith; Janelle M. Mayer; Francisco Gomez; John A. Thorson; Paul W. Naumann One approach to creating a state of iron deprivation in tumors is to expose them to monoclonal antibodies against the transferrin receptor (ATRAs). This paper reviews the recent history of studies...

... including DNA synthesis. Lymphocytes, similar to other cell types, respond to an increased Fe requirement during proliferation by increased synthesis and expression of surface transferrin receptors. Moreover, under transferrin-Fe-deplete conditions, certain lymphocyte lines exhibit other specialized...

.... The data presented in this paper suggest that TrR may play a regulatory role in cell differentiation and malignant transformation. Leukemic cells Differentiation Transferrin receptor 12 04 1985 24 09 1985 7 10 2008 © 1986 S. Karger AG, Basel 1986 Copyright / Drug Dosage...