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Keywords: T-cell proliferation
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Journal Articles

A fas Antigen Receptor Mutation Allows Development of Toxic Shock Syndrome Toxin-1 -Induced Lethal Shock in Vβ8.2T-Cell Receptor Transgenic Mice

Subject Area:
Further Areas , Oncology , Pathology and Cell Biology
Constance M. Cullen, Peter F. Bonventre, Holly Heeg, Horst Bluethmann, John D. Mountz, Carl K. Edwards, III
Journal: Pathobiology
Pathobiology (1995) 63 (6): 293–304.
https://doi.org/10.1159/000163965
Published Online: 08 October 2008
... with rTSST-1. These results suggested that the exquisite sensitivity of the MRL-lpr/lpr Vβ8.2 transgenic animals to rTSST-1 was not dependent exclusively on T-cell proliferation but was augmented by the influence of a defective fas antigen receptor expressed in homozygous Ipr mice. To test this hypothesis...
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