... cells did not produce a cure in the ia/ia recipients. These results suggest that the cellular source of the cure is a stem cell. This conclusion is further substantiated by the finding that Thy 1.1 antigen (a stem cell marker in the rat) is expressed on a majority of the cells from the donor sources...

...Emmanuelle Charafe-Jauffret; Florence Monville; Christophe Ginestier; Gabriela Dontu; Daniel Birnbaum; Max S. Wicha There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular subcomponent that has stem cell properties, that is, self-renewal...

... and stem cell self-renewal. It currently includes the canonical or Wnt/β-catenin pathway in which Wnt proteins bind to ‘frizzled’ receptors, which leads to downstream activation of gene transcription by β-catenin. Second, the noncanonical or β-catenin-independent pathways are now known to be mediated...