... on activin A production and its role in rheumatoid inflammation using freshly prepared rheumatoid synovial cells (fresh-RSC). Methods: Fresh-RSC from patients with rheumatoid arthritis were obtained and stimulated with multiple cytokines for activin A production. Gene expression levels of activin...

...Alisa E. Koch; Jon Friedman; James C. Burrows; George K. Haines; Noel P. Bouck Recently, we have shown that a macrophage subpopulation isolated from the synovial tissue of patients with rheumatoid arthritis was potently angiogenic and that a secreted inhibitor of angiogenesis, which is controlled...

... of TCR transcripts in synovial biopsies from individuals with early rheumatoid arthritis (RA) and non-RA synovitis. TCR α-chain transcripts were detectable in 5/5 RA and 4/4 non-RA specimens evaluated, with β-chain transcripts detected in 4/5 early RA and 4/4 non-RA specimens evaluated. Confirmation...

...Shigeru Hosaka; Manisha R. Shah; Nora Barquin; Kenneth Haines; Alisa E. Koch Angiogenesis is an integral component of the vasculoproliferative phase of rheumatoid arthritis (RA). We examined the distribution of two angiogenic factors, basic fibroblast growth factor (bFGF) and angiogenin (ANG...

... of nonrheumatoid origin. 12 08 1980 13 10 1980 8 10 2008 Rheumatoid arthritis Synovium Cellular antigens © 1981 S. Karger AG, Basel 1981 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...

...William V. Williams; Helga Rosenbaum; Robert B. Zurier Administration of γ-linolenic acid, which is converted rapidly to dihomo-γ-linolenic acid (DGLA), reduces joint swelling and tenderness in patients with rheumatoid arthritis. Joint tissue inflammation in patients with rheumatoid arthritis...

...Alisa E. Koch; James C. Burrows; Peter H. Domer; Richard A. Ashmun; Thomas Look; Joseph Leibovich We have selected several monoclonal antibodies (mAbs) produced using human rheumatoid arthritis (RA) synovial macrophages (mφs) as immunogen. Of these, mAbs 8H2, 10G7 and 10G9 showed cross reactivity...

... Chemistry and Medical Microbiology. University of Turku. Finland Key Words. Rheumatoid arthritis Synovial fibroblasts Mononuclear cells Fibroblast morphology Abstract. Effects o f peripheral blood mononuclear cells on cultured synovial fibroblasts were studied. When mononuclear cells from normal...

...A. Andreasen; P.K.A. Jensen; E. Jakobsen In an attempt to make well-defined cell culture systems, a method has been developed to produce clones of cells obtained from the synovial fluid of patients with rheumatoid arthritis and patients with HLA B-27 associated arthritis. A preliminary...

...Attila Balog; Gergely Klausz; János Gál; Tamás Molnár; Ferenc Nagy; Imre Ocsovszky; Zsófia Gyulai; Yvette Mándi Objectives: Infliximab, a chimeric anti-tumor necrosis factor (TNF) antibody, is highly effective for the treatment of Crohn’s disease (CD) and rheumatoid arthritis (RA). Our experiments...

...Qiong Fang; Yan-Yang Sun; Hani El-Gabalawy; Wei Cai; Linda Ko; Howard Chin; Thurayya Arayssi; H.Ralph Schumacher; WilliamV. Williams Rheumatoid arthritis (RA) has been postulated to result from a synovial immune response to an unidentified antigen(s), which should be mirrored by the T cell response...