... with features indicative of poor prognosis, including high histological grade, ER negativity, and HER2 positivity, and with poor patient outcomes. High KRT24 protein expression in chemotherapy-treated patients was significantly correlated with a shorter survival, a higher risk of distant metastases, and BC...

...Jun Yong Kim; Hoein Jeong; Aaron Valero Puche; Sanghoon Song; Soo Ick Cho; Minsun Jung Introduction: The tumor microenvironment plays a crucial role in the progression and prognosis of colorectal cancer (CRC). Among its components, the tumor-stroma ratio (TSR) and cancer-associated fibroblasts...

... microtubule-associated serine/threonine kinase like (MASTL), a cell cycle kinase required for a progression through mitosis, expression has been associated to poor prognosis. This study aimed to investigate the clinical relevance of MASTL expression in oral squamous cell carcinoma (OSCC) and a possible...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2024 Breast cancer Minichromosome maintenance complex component 7 Endocrine therapy Prognosis Molecular classes...

... as a significant independent predictor of poor DSS. Conclusion: Tumor-intrinsic perinuclear LOXL2 emerges as a clinically and biologically relevant feature associated with advanced disease, tumor aggressiveness, and poor prognosis in OSCC. Moreover, this study unprecedentedly uncovers a functional relationship...

... overall survival (OS) times. In multivariate analysis, PTB High and ITB High remained poor independent prognostic indicators of OS in DBDC patients. Specifically, ITB High could predict poor prognosis in patients with stage I (T1N0) DBDC. Conclusions: Both PTB High and ITB High were strong prognostic...

... (sCD15) for metastatic spreading. We analyzed the expression of CD15 and sCD15 in clear cell renal cell carcinoma (ccRCC) regarding prognosis. Methods: A tissue microarray containing tissue specimens of 763 patients with ccRCC was immunohistochemically stained for CD15 and sCD15, their expression...

... the outcomes in this notoriously recalcitrant genomic subset. In this review, we dissect the biology, classification, prognosis, current treatment landscape, and the early phase evaluation of investigational agents in TP53 -mutated AML and MDS. [email protected] [email protected] 6 03...

...-negative breast cancer Metastasis Prognosis Pleural effusion The initial search revealed a total of 265 consecutive pleural and peritoneal fluid samples from 132 patients diagnosed with metastatic breast cancer in their serous effusion cytology from January 2018 to October 2021. Following...

... < 0.001). High INCENP nuclear expression was predictive of poor prognosis in BC patients who received hormone treatment or chemotherapy. Conclusion: High INCENP expression is a poor prognostic biomarker in BC with potential therapeutic benefits. To confirm the prognostic significance of INCENP...

...-d UCSs have better prognosis. At the end of the study selection process, 11 studies [9, 10 , 14 - 22 ] with 783 patients were included (online suppl. Fig. 1; for all online suppl. material, see www.karger.com/doi/10.1159/000521876 ). Six studies performed immunohistochemistry for MMR proteins...

..., ALDH1/2 and Nanog in, respectively: 43 (68.2%), 30 (47.6%), 33 (52.4%), and 53 (84.1%) cancers. Analysing CD44, CD98, ALDH1/2, we have also shown that lack of CD44 overexpression indicates excellent prognosis in patients with HPV16 positivity. The aim of the present study was to compare prognostic...

...Ying Su; Ru Chen; Zhongcheng Han; Rong Xu; Lili Ma; Reyina Wufuli; Hongbo Liu; Fang Wang; Lei Ma; Rui Chen; Jiang Liu The aim of this study was to assess the relationship of cluster of differentiation 117 (CD117) expression with the clinicopathological characteristics and the prognosis in patients...

... progression. The immunoreactivity of AMACR and PAP could be useful for assessing prognosis in SDC, but immunohistochemical staining of prostate-specific markers should be interpreted with caution when determining whether a metastatic tumor is of prostate origin, especially when patients have a history of SDC...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pleuroparenchymal fibroelastosis Airways Prognosis Lung granulomas Pleuroparenchymal fibroelastosis is a rare form of upper-lobe...

...). Prognosis Smad4 protein GATA3 protein Breast cancer Breast cancer accounts for 23% of total cancer cases and is the most common cause of cancer death among females [ 1 ]. According to the hormonal status, histological type, and American Joint Committee on Cancer (AJCC) stage, patients with breast...

...). Interestingly enough, although not significant because of the limited number of nonsmokers, PD-L1+ TILs and TIMs were observable only in ever-smoking patients. Non-small cell lung cancer PD-L1 Prognosis The human immune system plays an important role in eliminating abnormal cells, which also...

... abnormalities with no specific pattern. Despite current therapeutic advances, the patients with STS still have a poor outcome, which makes it necessary to find out new prognostic markers. The Raf kinase inhibitory protein (RKIP) has been associated with prognosis in several human neoplasms; however, its role...

... and milli (m)-calpain are archetypal family members that require calcium for function and can be inhibited by their endogenous inhibitor calpastatin. This review describes the role of the calpain system in the prognosis of breast cancer and disease progression, in addition to the role of the calpain system...

... telomere reverse transcriptase (hTERT) is one of AKT's tumorigenic effects. In this study, the significance of AKT phosphorylation and hTERT on prognosis of gastric cancer were examined. AKT activation by epidermal growth factor increased hTERT expression and telomerase activity. In contrast, AKT...