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Keywords: Progerin
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Journal Articles
Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei
Available to PurchaseHelal Endisha, Jacqueline Merrill-Schools, Min Zhao, Molly Bristol, Xu Wang, Nard Kubben, Lynne W. Elmore
Journal:
Pathobiology
Pathobiology (2015) 82 (1): 9–20.
Published Online: 28 February 2015
... (HGPS). Thus, we sought to test whether levels of SIRT6 are reduced in cells from individuals with HGPS and whether restored SIRT6 expression may impede premature aging phenotypes. Methods: Levels of endogenous SIRT6 and progerin in HGPS and normal fibroblasts were assessed by Western blotting...
