...T. Gaillard; A. Mülsch; R. Busse; H. Klein; K. Decker Macrophages have been described to release nitric oxide (NO) as a cytotoxic radical. This highly unstable substance is as well known as endothelium-derived relaxing factor produced by vascular endothelial cells. Because of its cytotoxic activity...

...-deficient mice. Thus, nonselective ET receptor antagonists may have a therapeutic potential in the treatment of human atherosclerotic disease. 19 10 2001 Endothelins Atherosclerosis Antagonists Nitric oxide Hypercholesterolemia © 2001 S. Karger AG, Basel 2001 Copyright / Drug Dosage...

...Carlos Alberto Mandarim-de-Lacerda; Leila Maria Meirelles Pereira Objective: The myocardial effect on the normalization of arterial blood pressure in animals with hypertension previously induced by nitric oxide synthesis (NOS) inhibition is still unknown. The purpose of this study was to estimate...

... forming the structural framework of the myocardium. Hypertension was induced by long-term low-dosage inhibition of nitric oxide synthesis by N G -nitro-L-arginine methyl ester (L-NAME) in rats. L-NAME (12 mg/kg) was given to animals in water ad libitum during 15 weeks. After this period, systolic blood...