... of recent onset (average disease duration of 10 ± 3 months) to assess the involvement of monocytes/macrophages during the early stages of SSc. All SSc skin biopsies displayed inflammatory microvascular endothelial cell activation and fibrosis. Increased numbers of infiltrating inflammatory leukocytes were...

... on human monocytes, ‘aged monocytes’ (isolated from individuals > 65 years of age) were compared with ‘young monocytes’ (isolated from individuals -25 years of age) for their ability to be activated by lipopolysaccharide. Our results show that aged monocytes display a decrease in their cytotoxicity...

...Subhash Dhawan; Alonso Heredia; Larry M. Wahl; Jay S. Epstein; Monte S. Meltzer; Indira K. Hewlett We have previously shown that the treatment of monocytes with interferon-γ (IFN-γ) prior to exposure with human immunodeficiency virus type-1 (HIV) results in complete inhibition of HIV infection...

...P. Kierulf; Å.-B.W. Andersen Cryopreserved human monocytes have been examined for their procoagulant and profïbrinolytic capacities on lipopolysaccharide (LPS) stimulation, when given the possibility to act upon fibrinogen in heparinized plasma. As shown by the appearance of fibrinopeptide...

...Monte S. Meltzer; Lisa Baca; Jim A. Turpin; Chester Kalter; Carl Dieffenbach; Robert M. Friedman; Howard E. Gendelman Monocytes treated with interferon-α (IFN-α) at virus challenge show no evidence of human immunodeficiency virus (HIV) infection: no p24 antigen or reverse transcriptase (RT...

...R. Esser; H. von Briesen; W. Brugger; M. Ceska; W. Glienke; S. Müller; A. Rehm; H. Rübsamen-Waigmann; R. Andreesen Apart from lymphocytes, mononuclear phagocytes play an essential role as target cells for human immunodeficiency virus (HIV). Circulating blood monocytes (MOs) and tissue macrophages...

..., and the viral protein EBNA-2 is involved in mediating this effect. The only normal cells in which the c-fgr gene is known to be expressed are peripheral-blood granulocytes and monocytes, and tissue macrophages. In accordance with this, levels of c-fgr mRNA increase when the human promonocytic cell line U937...

... cases, the brain monocytes/macrophages and the microglial cells are the only cells which replicate HIV in the central nervous system (CNS) of these patients, and the appearance of neurological symptoms seems induced by an interaction between HIV-infected macrophages with neurons and glial cells. AIDS...

... by two different sources of monocytes. LPS-HDL complexes were purified by ultracentrifugation in sodium bromide gradients. The human monocytic cell line THP-1 and the freshly isolated human monocytes, purified by adherence or elutriation from venous blood from healthy donors, were exposed to medium alone...

...H.-D. Flad; E. Grage-Griebenow; F. Petersen; B. Scheuerer; E. Brandt; J. Baran; J. Pryjma; M. Ernst Survival or apoptosis, activation and differentiation, phagocytosis and antigen presentation, migration or participation in granuloma formation are features of freshly recruited blood-borne monocytes...

...) and human monocytes were used to investigate the role of various cytokines in the regulation of C-C and C-X-C chemokine production. We have demonstrated that IL-4 and IL-10 negatively affect certain monocyte-derived chemokines, while not suppressing HUVEC-derived chemokines. The differential induction...