... O’Valle Ravassa Introduction: Insulin-like growth factor-II messenger RNA-binding protein-3 (IMP3) over-expression is a predictor of tumor recurrence and metastases in some types of human melanoma. Our objective was to evaluate the immunohistochemical expression of IMP3 and other molecules related...

...Liang Sheng; Rong Wei Background: Melanoma is one of the most aggressive and high mortality skin cancers in the world. Long non-coding RNA-CASC15, as a carcinogen, plays an important role in a variety of tumorigenesis; however, the role and underlying mechanism of CASC15 in melanoma remain unclear...

...Faruk Tas; Kayhan Erturk Background/Aims: Acral lentiginous melanoma (ALM) is a small subtype of melanoma affecting Caucasians far more often than other ethnic groups, such as blacks, Hispanics, and Asians. Only a few studies have yielded controversial results on ALM so far. The aim of this study...

... or melanoma, and mesenchymal skin cancers such as angiosarcoma and dermatofibrosarcoma protuberans (DFSP) have identified new molecular targets for a systemic or local treatment approach. For DFSP there is an opportunity already today to reduce the intensity of surgical procedures by pretreatment...

...Danny R. Welch; Steven F. Goldberg Progression from normal melanocyte to metastatic melanoma is a multistep, multigenic process. While relatively easy to conceptualize, the stages of melanoma progression are not necessarily discrete, nor are they unambiguously defined at the morphologic...

...J. Lunec; C. Pieron; G.V. Sherbet; A.J. Thody Using a radioimmunoassay specific for α-melanocyte-stimulating hormone (α-MSH), significant levels of immunoreactivity were detected in a range of murine and human melanoma cell lines, including a series of ras-transfected melanocytes. The levels found...

.... Accordingly, we discuss the known protein antigens of murine melanoma with emphasis on those expressed by more than one species. These include six mouse-specific and five cross-species antigens, and 1 human antigen transfected into mouse cells. Of the five cross-species antigens, B700 and HMW have been...

...G.V. Sherbet The membrane fluidity of murine B16 melanoma and L5178 lymphoma variants is examined in relation to their metastatic potential. A higher lateral mobility of membrane proteins in metastasis is indicated by lectin receptor-mediated agglutination studies, but these do not constitute...

... melanoma cells, and the animals were sacrificed 3–7 days after tumor cell injection. The results show that early metastases are made up of avascular nodules of tumor cells, which subsequently developed lacunae which are not lined by endothelial cells and usually contain blood cells. A more developed...

...Daniel C. Adelman; Kent L. Erickson; Eric Gershwin The effects of macrophages or sera from tumor-transplanted or control syngeneic and allogeneic mice on the latency and growth rate of P51 murine melanoma cells were determined after transplantation into congenitally athymic (nude) mice (tumor...

...Joel Abramowitz; Walter Chavin The acute in vitro action of adrenocorticotropin (ACTH) and corticosterone alone and in combination were determined in the Cloudman S-91 melanoma grown in vivo. Hormone-treated melanoma dice (5-240 min) were analyzed for tyrosinase activity (EC 1.14.18.1), cyclic AMP...

...L. Helson; C. Helson; S. Green A partially purified glycoprotein fraction (the G-200 II fraction) obtained from sera of CD-1 mice sensitized with Cory nebacterium parvum and treated with endotoxin was designated as tumor necrosis factor (TNF). Human melanoma cells exposed to this factor in vitro...

... is the most important objective now. Fludarabine (FLU), a known anticancer drug, has been shown to downregulate Treg cells in vivo in chronic leukemia patients. Melanoma tumor antigen Mart-1 27–35 -specific CD8+ CTLs generated in vitrowith total peripheral blood lymphocytes (PBL) lose their activity within 14...

... the recognition of DCs as the professional APC, the paradigm has emerged that macrophage (Mφ) are scavengers and are incapable of activating T cells. Method: The melanoma-associated MART-1 27–35 peptide-loaded Mφ from HLA-A2-positive donors were used to activate MART-1 27–35 epitope-specific CTL in vitro. Results...

... of human malignancies. The main aim of this study was to investigate retinoblastoma gene expression in the full spectrum of melanoma progression from naevus to melanoma metastases by applying immunohistochemistry and RT-PCR. All naevi with and without dysplasia showed high expression of the retinoblastoma...

...Menashe Bar-Eli Expression of interleukin-8 (IL-8) by human melanoma cells correlates with their metastatic potential in vivo. Moreover, UVB irradiation of primary cutaneous melanoma induces IL-8 mRNA and protein production and increases both tumor growth and metastasis in nude mice. Although IL-8...