..., and podoplanin) in the intratumoral and marginal areas of 133 sarcomas. We also examined the association between these markers, as well as the number of CD163-positive macrophages (i.e., tumor-associated macrophages), and clinical outcome. Results: In all cases, the log-rank test revealed that those with high...

...Thomas Menter; Alexandar Tzankov It has become evident that the microenvironment – lymphocytes, macrophages, fibroblasts as well as the extracellular matrix, cytokines, chemokines, and a plethora of other cells, structures and substances residing in the vicinity of tumor cells – plays an important...

...Eric Bernasconi; Fabrizia D'Angelo; Pierre Michetti; Dominique Velin Objective: Macrophages play a critical role in intestinal wound repair. However, the molecular pathways that regulate macrophage wound repair activities remain poorly understood. The aim of this study was to evaluate the role...

... pneumonia patients. Neutrophilic granulocytes and various lymphocyte and macrophage subpopulations were immunohistochemically quantified on lung tissue specimens of young (n = 5; mean age 8.4 years), middle-aged (n = 8; mean age 55.9 years) and elderly (n = 9; mean age 86.6 years) pneumonia patients...

...Zoé Enderlin Vaz da Silva; Hans-Anton Lehr; Dominique Velin Objective: Macrophages play a critical role in wound repair. However, the specific role of the different macrophage subtypes in wound repair remains incompletely understood. The aim of this study was to compare the wound repair activities...

... patients with prostate cancer. All patients underwent radical prostatectomy. We assessed the number of infiltrating T cells (CD3 + ), B cells (CD20 + , CD79alpha + ), and macrophages (CD68 + , CD204 + ) in benign and malignant prostate tumors. Results: CD68 + macrophages infiltrated benign glands...

..., but the microenvironmental composition is of prognostic importance. Recently, the number of CD68-positive macrophages was correlated with adverse survival in HL, and there was a call to validate these results. Methods: We utilized immunohistochemistry to analyze the prognostic importance of the CD68-positive macrophage...

...Yukiko Moriwaka; Yi Luo; Hitoshi Ohmori; Kiyomu Fujii; Naokuni Tatsumoto; Tomonori Sasahira; Hiroki Kuniyasu Background: Cancer-secreted high mobility group 1 (HMGB1) induces apoptosis of macrophages and suppresses the host anti-cancer immune system. Objective: We here examined the effect of HMGB1...

... of recent onset (average disease duration of 10 ± 3 months) to assess the involvement of monocytes/macrophages during the early stages of SSc. All SSc skin biopsies displayed inflammatory microvascular endothelial cell activation and fibrosis. Increased numbers of infiltrating inflammatory leukocytes were...

...Jianglin Fan; Tatsuro Shimokama; Osamu Tokunaga; Teruo Watanabe Intimal infiltration of lipid-filled macrophages (Mφs) is an important event in the pathogenesis of atherosclerosis. To better understand Mφ functions, a model for the extravascular in vivo generation of foam cells in rat peritoneal...

... the present study to determine whether increased applied pressure could alter uptake of IgG complexes by macrophages. Increased pressure was applied to confluent macrophages grown on plastic culture plates using a pressure chamber apparatus kept inside the incubator at 37 °C and pressure regulated using...

... injections of asbestos fibers. After exposure to asbestos fibers, monocytes were recruited into the abdominal cavity and acquired the characteristics of inflammatory or nonspecifically activated macrophages. Nontoxic titanium dioxide or toxic silica particles did not produce activation of the free peritoneal...

...L. Kopper; Tran Van Hanh; C. Hegedüs; K. Lapis The growth of human colorectal tumor xenograft lines was studied in immunosuppressed mice after reconstitution with sensitized and nonsensitized macrophages, thymocytes and splenocytes obtained from normal mice. Intravenously injected macrophages...

... between the two groups in the planimetric extent of atheromata in the aortae. GdCl 2 treatment inhibited the deposition of sudanophilic lipids in depth of the arterial wall. The findings indicate that macrophages are the primary foam cells and their uptake of lipoproteins is essential for the deposition...

...E. Holler; R. Hintermeier-Knabe; H.J. Kolb; J. Kempeni; A. Möller; S. Liesenfeld; L. Daum; W. Wilmanns To investigate the role of tumor necrosis factor-α (TNF-α) released by activated macrophages, sequential serum samples of 120 patients undergoing bone marrow transplantation (BMT) were analyzed...

...Carol A. Nacy; Anda I. Meierovics; Miodrag Belosevic; Shawn J. Green Expression of activated macrophage resistance to infection requires the cooperative interaction of interferon-γ (IFN-γ) and either interleukin-2 (IL-2), interleukin-4 or granulocyte/macrophage-colony-stimulating factor: no single...

...F. Vincent; A. Eischen; H. de la Salle; J.P. Bergerat; A. Faradji; G. Hauptman; F. Oberling In order to analyze the kinetics of complement component synthesis by human monocytes/macrophages, we have developed a system of defined culture conditions in the absence of serum. Moreover, the use...

...Rainer Zawatzky; Angela Homfeld In macrophages from inbred mice the magnitude of the interferon (IFN) response to Newcastle disease virus (NDV) infection is under genetic control of the locus If-1, with C57BL/6 carrying the ‘high-producer’ allele If-l h whereas BALB/c have the ‘low-producer’ allele...

...T. Gaillard; A. Mülsch; R. Busse; H. Klein; K. Decker Macrophages have been described to release nitric oxide (NO) as a cytotoxic radical. This highly unstable substance is as well known as endothelium-derived relaxing factor produced by vascular endothelial cells. Because of its cytotoxic activity...

...R. Esser; H. von Briesen; W. Brugger; M. Ceska; W. Glienke; S. Müller; A. Rehm; H. Rübsamen-Waigmann; R. Andreesen Apart from lymphocytes, mononuclear phagocytes play an essential role as target cells for human immunodeficiency virus (HIV). Circulating blood monocytes (MOs) and tissue macrophages...