... be encountered, including reactive lesions and oral potentially malignant disorders, and it is difficult to differentiate OSCC from these lesions based on both clinical and histopathological findings. It is well known that chronic inflammation contributes to oral cancer development. Macrophages are among...

...Maiko Okamoto; Yu-ichiro Koma; Takayuki Kodama; Mari Nishio; Manabu Shigeoka; Hiroshi Yokozaki Objectives: Growth differentiation factor 15 (GDF15), which is derived from tumor-associated macrophages (TAM) and cancer cells, promotes progression of esophageal squamous cell carcinomas (ESCC). However...

... macrophage plays an important role in tumor progression. Therefore, we examined STAT3 activation, cytokine expression and infiltration of tumor-associated macrophages in resected HCCs as well as the alteration of cell growth and migration by cytokine stimulation in HCC cell lines. Methods...

...E.D. Shields; P.B. Noble; D. Radzioch A novel computerized methodology was used to quantify, for the first time, the 3-dimensional locomotory phenotypes of individual macrophages moving within an extracellular matrix-like hydrated collagen lattice/gel. Comparisons between two macrophage lines...

...Michael J. Myers; Dorothy E. Farrell; Mark Henderson The immunomodulatory effect of oxytetracycline (OTC) on murine splenic lymphocytes (MSL), peritoneal exudate macrophage (PEM) functions and antibody production was examined. In vivo exposure to OTC slightly delayed initiation of antibody...

...Shengyuan Yu; Peigen Kuang; Takemichi Kanazawa; Kogo Onodera; Hirohumi Metoki; Yasaburo Oike Mouse peritoneal macrophages were incubated in DMEM medium with batroxobin (DF-521) to determine the effect of batroxobin on the internalization of peroxidized low-density lipoprotein (pox-LDL...

...Alisa E. Koch; James C. Burrows; Peter H. Domer; Richard A. Ashmun; Thomas Look; Joseph Leibovich We have selected several monoclonal antibodies (mAbs) produced using human rheumatoid arthritis (RA) synovial macrophages (mφs) as immunogen. Of these, mAbs 8H2, 10G7 and 10G9 showed cross reactivity...

...Guido Poli; Anthony S. Fauci The monocyte/macrophage system, which is characterized by a high degree of heterogeneity, is a target of the human immunodeficiency virus (HIV) in vitro as well as in vivo. Both bone-marrow-derived precursor elements and circulating monocytes are infectable in vitro...

...Ronald Collman Human immunodeficiency virus (HIV) infects cells of the monocyte/macrophage lineage in addition to lymphocytes, and infection of these cells may be responsible for viral persistence and dissemination, encephalopathy of the acquired immunodeficiency syndrome and other sequelae of HIV...

... substrate. Lysosomal N-acetyl-β-Z)-glucosaminidase and acid phosphatase activity was detected in neoplastic astrocytes at a level of enzymatic activity equal to that of monocyte/macrophage cell lines in certain glioma cells. From the implication of this data, it is suspected that astrocytes may function...

... in inflamed joints. The host factors as well as the microbial antigens responsible for the initiation of the arthritic process are unknown. The pathogenesis of reactive arthritis is discussed here with special reference to the intracellular life of the causative microbes and to monocytes/macrophages, which...

...Masakuni Sugimoto; Yoshihisa Wakabayashi; Shun-ichi Hirose; Martin J. Murphy, Jr The effect of peritoneal macrophage-conditioned medium (macrophage CM) from lipopolysaccharide-injected mice on granulocyte-macrophage colony (CFU-gm) and megakaryocyte colony (CFU-meg) formation was examined using...

...Sukh Mahendra Singh; Ajit Sodhi Murine peritoneal macrophages treated with cisplatin (10 µg/ml) showed increased binding to Dalton’s lymphoma cells in vitro. Macrophages and target cells both extend cytoplasmic extensions towards each other, which finally join and fuse to form a distinct...

...A. Donna; P.G. Betta; G. Lanfranco The authors studied the activity of acid and alkaline phosphatase in macrophages of Tenebrio molitor larvae stimulated with various types of asbestos: A and B chrysotile, crocidolite, amosite and anthophyllite. The activity of the two enzymes increased, as did...

...P. Badenoch-Jones Phorbol myristate acetate (PMA) at nanomole concentrations induces a rapid aggregation of guinea pig macrophages. This aggregation is dependent on extracellular Mg 2+ (but not Ca 2+ ) for its development. Additionally, it is inhibited by some agents which also inhibit aggregation...

...R. Hammer; D.D. Joel; M.E. LeFevre The ultrastructure of macrophages located in the dome of murine Peyer’s patches was examined by transmission electron microscopy. Aggregates of carbon particles as well as numerous other phagocytic and lysosomal inclusions were consistently observed in dome...

...Daniel C. Adelman; Kent L. Erickson; Eric Gershwin The effects of macrophages or sera from tumor-transplanted or control syngeneic and allogeneic mice on the latency and growth rate of P51 murine melanoma cells were determined after transplantation into congenitally athymic (nude) mice (tumor...

...Alisa E. Koch; James C. Burrows; Robert Marder; Peter H. Domer; Joseph Leibovich We have characterized antimyeloid monoclonal antibodies (mAbs) produced to human rheumatoid arthritis (RA) synovial tissue macrophages (MPs) (8D7) and to lipopolysaccharide (LPS)-treated U937 cells (3D8). The 3D8...

...Günter Schwamberger; Inge Flesch; Ernst Ferber Activated macrophages secrete a variety of factors affecting proliferation or viability of neoplastic cells. Factors described previously are discussed for their relevance as effector molecules for the selective destruction of tumor cells by activated...

...Victoria Kolb-Bachofen Rat liver macrophages express a galactose-specific receptor which mediates endocytosis of particles or neuraminidase-treated blood cells. From rat serum we now have isolated a galactose-specific lectin by affinity chromatography. Comparative analysis of this serum galactose...