...András Vörös; Erika Csörgő; Tibor Nyári; Gábor Cserni Objective: The Ki-67 proliferation index has received an important role in treatment tailoring and molecular classification of estrogen receptor-positive breast carcinomas. The aim was to analyze the reproducibility of assessing proliferation...

... D1 expression with low Ki-67 activity. However, little is known about the expression of cell cycle regulators in the other types of multinucleated giant cells. We aimed to investigate the cell cycle status of multinucleated giant cells. Methods: The immunohistochemical expressions of cyclin D1, p16...

...Saudade André; António E. Pinto; Cátia Laranjeira; Manuela Quaresma; Jorge Soares Aim: The purpose of this study was to compare the immunohistochemical profile of cell cycle inhibitors of G1/S phase transition (p21, p53 and pRb), Ki-67 proliferation marker and DNA ploidy in male (MBC) and female...

...Kiyoshi Hashimoto; Kunio Araki; Mitsuhiko Osaki; Hiroshige Nakamura; Katsuyuki Tomita; Eiji Shimizu; Hisao Ito Objective: The expressions of minichromosome maintenance protein 2 (MCM2), Ki-67, and p53 were examined to analyze their pathobiological significance in human lung adenocarcinomas. Methods...

... maintenance 2 (MCM2). Methods: This study analyzed 12 patients with normal oral epithelia, 69 with dysplasia, and 35 with squamous cell carcinoma (SCC); in 13 patients, SCCs were preceded by dysplasia. The sections were immunostained for MCM2, Ki-67, P53, P27 Kip1 and P21 CIP1/WAF1 , and conducted by TUNEL...

... IIα. For each case, a topo IIα index was determined by image analysis. Similar indexes were available for Ki-67 protein, a known cell proliferation marker, and p53, bcl-2 and c-erbB-2 oncoproteins. Each case had been staged and graded and the patients had been followed up for a mean period of 61.62...