..., or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Iron...

...Jan Kovar; Laura L. Stunz; Barbara C. Steward; Karin Kriegerbeckova; Robert F. Ashman; John D. Kemp We found that the mouse B cell lymphoma 38C13 underwent apoptosis in vitro when deprived of iron by three independent methods: (1) exposure to a synergistic pair of rat IgG monoclonal antibodies...

...Christopher R. Chitambar; Jana Narasimhan While iron is essential for numerous intracellular processes, its critical role in DNA synthesis relates to the activity of the iron-containing M2 subunit of ribonucleotide reductase, the enzyme responsible for the synthesis of deoxyribonucleotides. Gallium...

...Nava Shterman; Batya Kupfer; Chaya Moroz We studied the mode of iron transport and storage in a human breast cancer cell line (HT-24) in comparison with a breast epithelial cell line (HBL-100). It was found that HT-24 cells incorporated over 18 h more 59 Fe as compared to HBL-100 (24 vs. 16%). Yet...

...Howard H. Sussman Iron participates in a range of reactions that are necessary for cell viability and cell proliferation. Iron is an essential component in DNA synthesis and in respiratory and oxidative metabolism. These functions relate to the properties of unremitting proliferation and a more...