.... When addressing these features, it is very important to acknowledge the issue of tumour heterogeneity, as it imposes several questions. First of all, lung cancer is a very heterogeneous disease, at a cellular and histological level. Cellular and histological heterogeneity are addressed with emphasis...

... that the morphological heterogeneity of BC reflects an underlying spectrum of genetic and epigenetic portraits that control BC behaviour. Further understanding of BC heterogeneity will have an impact, not only on the routine diagnostic practices but also on patients' management decisions. Phenomena like diagnostic...

...Xavier Sagaert; Arno Vanstapel; Sanne Verbeek Colorectal cancer is not one disease but rather a collection of neoplastic diseases. Due to heterogeneity in the disease biology, therapy response, and prognosis, extensive disease stratification is required. Therefore, TNM stage, microsatellite status...

..., this heterogeneity is not limited to histopathological diversity only but is also manifested as variation in several genetic and/or epigenetic alterations, the numbers of interactions between the tumour and surrounding microenvironment, and interpatient differences, for example. All these factors contribute...

...Yuri Tolkach; Glen Kristiansen Prostate cancer is a paradigm tumor model for heterogeneity in almost every sense. Its clinical, spatial, and morphological heterogeneity divided by the high-level molecular genetic diversity outline the complexity of this disease in the clinical and research settings...

.... Tremendous efforts have been made to characterize these subtypes and identify tumoral pathways and potential biomarkers for therapeutic strategies. As in other cancer types, tumor heterogeneity appears to be very high across subtypes and within a single tumor, representing a major cause of treatment failure...

... Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involving CRTC1 and CRTC3-MAML2 genes in mucoepidermoid carcinoma and MYB-NFIB fusion in adenoid cystic carcinoma). Carcinoma ex pleomorphic adenoma shows diversity in its histological appearance, but recurrent rearrangements...

...Sònia Gatius; Dolors Cuevas; Carlos Fernández; Berta Roman-Canal; Virginia Adamoli; Josep Maria Piulats; Núria Eritja; Mireia Martin-Satue; Gema Moreno-Bueno; Xavier Matias-Guiu Endometrial carcinoma (EC) shows intertumor heterogeneity, with several different histologic types differing...

... stages of differentiation and activation. These mAbs should prove to be a valuable tool for studying heterogenous populations of myeloid cells. Rheumatoid Macrophage Heterogeneity Monoclonal antibodies © 1990 S. Karger AG, Basel 1990 Copyright / Drug Dosage / Disclaimer Copyright: All...

...Masakazu Fujiwara; Enjing Jin; Mohammad Ghazizadeh; Oichi Kawanami Objective: Protease-activated receptors (PARs) mediate DNA synthesis in endothelial cells when activated by serine proteases. However, despite the existence of heterogeneity among endothelial cells from each tissue, the responses...