...Christopher C. Broder; Dimiter S. Dimitrov The recent discovery of a chemokine receptor, fusin (fusin/CXCR-4), as the long-sought human immunodeficiency virus type 1 (HIV-1) coreceptor opened an entirely new field of aquired immunodeficiency syndrome (AIDS) research on mechanisms of viral entry...

...A.P. Achord; R.E. Lewis; M.N. Brackin; H. Henderson; J.M. Cruse Previously, we have shown that CD4 levels in African Americans infected with human immunodeficiency virus-1 (HIV-1) were lower than those in Caucasians. To determine whether or not HLA type is associated with susceptibility to HIV-1...

...Muhammad Shahabuddin; Barbara Volsky; Helen Kim; Koji Sakai; David J. Volsky Human neural cells are susceptible to infection with human immunodeficiency virus type 1 (HIV-1) in vitro; however, virus replication in these cells is strongly restricted. To understand the mechanism of this restriction...

...Premkumar Reddy; Purandar Dasgupta The human CD4+ T lymphocytes in the peripheral blood represent a major target for HIV-1 infection in vivo. In the quiescent state T lymphocytes are nonpermissive for the propagation of HIV-1. Antigenic or mitogenic stimulation of T lymphocytes triggers a cascade...

...William A. O’Brien Cells of mononuclear phagocyte lineage are the predominant cell type producing human immunodeficiency virus type 1 (HIV-1) in extravascular tissues; HIV-1 infection of mononuclear phagocytes may be directly related to primary disease manifestations and also appears to contribute...

... of virus production. Our mapping studies suggest that fewer than five human chromosomes are necessary for reconstituting infectivity in the murine background. These results have implications for models of HIV-induced pathogenesis and infectivity. Genes Facilitate HIV-1 Infection Pathobiology 1991;59:361...

...Rebecca L. Edgeworth; Kenneth E. Ugen With the global rise in human immunodeficiency virus-1 (HIV-1) infection in women of childbearing age, there has also been an alarming rise in the number of mother-to-child transmissions of HIV-1. Although drug therapies such as zidovudine as well as nevirapine...