... cells get access into the vascular lumina, they have to detach themselves from the growing tumour cell mass, followed by invasion and migration through the extracellular matrix (ECM) towards the vascular walls [ 46 ]. These steps are, therefore, considered prerequisites for the LVI process. Malignant...

... and Turku University Hospital, Turku, Finland Key Words Fibrosis Matrix metalloproteinase(s) Interstitial collagenase Adenoviral gene transfer Extracellular matrix Hepatocyte growth factor Abstract Objective: To evaluate the role of matrix metalloproteinase (MMP)-13 gene expression in the early...

...Tobias Schulz; Udo Schumacher; Christian Prante; Wolfgang Sextro; Peter Prehm Objectives: Hyaluronan, a major water binding component of the extracellular matrix, is synthesised within the cytosol and exported across the plasma membrane by the ABC-transporter MRP5 in fibroblasts. Although its...

... mice Extracellular matrix Histochemistry Histopathology Macrophage colony-stimulating factor © 2009 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized...

... or altered expression of the extracellular matrix glycoprotein tenascin (Tn). Mesenchymal cell constituents of normal adult organs show only a very limited tendency to deposit Tn in their extracellular matrix. In the present study, we investigated whether malignant human mesenchymal cells derived from...

... stromal cells grew into round clusters of mainly fusiform cells. Transmission electron micrographs showed collagen fibers between stromal cells as well as in surrounding extracellular matrix after 2.5 weeks. A well-defined basement membrane was found when epithelial and stromal cells were in close...

... been previously described for normal keratinocytes induced to differentiate by a variety of means. The changes in biological properties were accompanied by alterations in production of extracellular matrix components – e.g., fibronectin and thrombospondin. Synthesis of both components was decreased...

... of metastasis. In the present study we attempted to determine more accurately the stage in which they differ. The HM cells attached less efficiently than the LM ones to both endothelial cells (5 times) and extracellular matrix (twice), possibly indicating a more efficient extravasation capacity of the HM cells...

... preneoplastic lesions. 19 03 1987 29 09 1987 7 10 2008 Hyaluronic acid CL-S1 cell line Extracellular matrix Growth response Tumor progression Glycosaminoglycan Mammary epithelium © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

...Rosemarie B. Lichtner; Paula N. Belloni; Garth L. Nicolson The in vitro adhesion rates of rat 13762NF mammary adenocarcinoma cell clones of different spontaneous metastatic potentials to cloned microvessel endothelial cell monolayers and their subendothelial extracellular matrix were investigated...

...Keiko Watanabe; Shuji Toda; Nobuhisa Yonemitsu; Hajime Sugihara F9 teratocarcinoma stem cells treated with retinoic acid (RA) differentiate into visceral endoderm, and this process affects the expression of some extracellular matrix (ECM) proteins. As the direct influence of ECM molecules...

... molecular and protein analysis must be integrated. Basement membrane Development Glomerulus Laminin Extracellular matrix 1999 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...