... mechanistic link with epithelial-mesenchymal transition (EMT). Methods: Immunohistochemical analysis of MASTL, E-cadherin, vimentin, and Smad7 was performed in paraffin-embedded tissue specimens from 148 OSCC patients. Results: Nuclear MASTL expression was detected in 115 (77.7%) OSCC specimens. High MASTL...

... Oral squamous cell carcinoma Lysyl oxidase-like 2 YAP1 Epithelial-mesenchymal transition Prognosis Oral squamous cell carcinoma (OSCC), the most common histopathologic form of oral cancer, is one of the most prevalent cancers worldwide [ 1 ]. Five-year survival rates range between 15...

..., namely the C57BL/6 serum group (group 1), the MRL/lpr serum group (group 2), the MRL/lpr serum + siRNA-negative control group (group 3), and the MRL/lpr serum + siRNA-YAP1 group (group 4). Epithelial-mesenchymal transition (EMT) markers in each group were detected by Western blotting...

... knockdown and overexpression experiments, we showed that high-level expression of HOTAIR promotes epithelial-mesenchymal transition (EMT) in 60As6 cells. By luciferase assay, we found that HOTAIR directly targets and binds to miR-217, and that miR-217 directly binds to Zinc finger E-box-binding homeobox 1...

.... Methods: Quantitative real-time polymerase chain reaction was applied to explore CASC15 and β-catenin expression in melanoma tissues and cells. Western blotting was carried out to investigate β-catenin, glycogen synthase kinase-3β, Survivin, Bax, Bcl-2, and epithelial–mesenchymal transition (EMT)-related...

... of the acquired immune system, and 2 patients showed recurrence thereafter. All recurrent tumors highly expressed CD47 and CD44 and showed the epithelial-mesenchymal transition (EMT) phenotype. Our results suggest that CD47 promotes the malignancy of CRC in association with EMT and enhances the stemness of cancer...

... underlying peritoneal dissemination from the viewpoint of microRNA (miRNA) expression. Results: miRNA array and qRT-PCR analysis showed that the expressions of epithelial-mesenchymal transition (EMT)-associated miRNAs such as miR-200c and miR-141 were significantly low in 58As9. Using 58As9 with stably...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Breast carcinoma Epigenetics Epithelial-mesenchymal transition Extracellular matrix Invasion Lymphangiogenesis Lymphovascular invasion Migration Tumorigenesis LVI denotes...

... of exogenous WNT5A expression into MKN-7 cells upregulated genes related to the epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs), and the pWNT5A transfectant showed high tumorigenicity in vivo. These results were confirmed by knockdown experiments using a lentivirus expressing shWNT5A...

... cells, as CTCs generated in the process of epithelial-mesenchymal transition (EMT) can bear features characteristic of CSCs. This article describes the mechanisms of CTC and CSC formation and characterizes their molecular hallmarks. Moreover, we present different types of EMT occurring in physiological...

...). Conclusion: Epithelial caveolin-3 expression is increased in AC compared to PTC and DSVPC, and this may be linked to the epithelial-mesenchymal transition process of AC. In addition, stromal caveolin-1, caveolin-2 and caveolin-3 expression was more frequent in AC compared to PTC and DSVPC, and the specific...

...) and hypoxia (CAH1, PSB6, and ACTG) were influenced by MMF in fibrotic conditions. Moreover, MMF may modulate antifibrotic and apoptotic pathways as well as epithelial-mesenchymal transition (EMT). Different signaling pathways may be influenced by MMF therapy. These results suggest an inhibitory effect of MMF...

...Risayo Masuda; Shuho Semba; Eri Mizuuchi; Kazuyoshi Yanagihara; Hiroshi Yokozaki Objective: Tricellulin plays a central role in the sealing of epithelia at tricellular contacts. We examined the effects of Snail, an epithelial-mesenchymal transition (EMT)-related transcription factor...