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Keywords: Deferoxamine
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Journal Articles

Differing Sensitivity of Non-Hematopoietic Human Tumors to Synergistic Anti-Transferrin Receptor Monoclonal Antibodies and Deferoxamine in vitro

Subject Area:
Further Areas , Oncology , Pathology and Cell Biology
Jan Kovar, Paul W. Naumann, Barbara C. Stewart, John D. Kemp
Journal: Pathobiology
Pathobiology (1995) 63 (2): 65–70.
https://doi.org/10.1159/000163935
Published Online: 08 October 2008
...Jan Kovar; Paul W. Naumann; Barbara C. Stewart; John D. Kemp We tested non-hematopoietic human tumors for in vitro sensitivity to either a pair of synergistic IgG antitransferrin (Tf) receptor monoclonal antibodies (MAbs), deferoxamine (DFO) or the combination thereof. With an equimolar mixture...
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Journal Articles

Direct Evidence That Iron Deprivation Induces Apoptosis in Murine Lymphoma 38C13

Subject Area:
Further Areas , Oncology , Pathology and Cell Biology
Jan Kovar, Laura L. Stunz, Barbara C. Steward, Karin Kriegerbeckova, Robert F. Ashman, John D. Kemp
Journal: Pathobiology
Pathobiology (1997) 65 (2): 61–68.
https://doi.org/10.1159/000164105
Published Online: 08 October 2008
... against the mouse transferrin receptor; (2) exposure to the iron chelator deferoxamine (DFO), and (3) exposure to a defined culture medium without any added iron (iron-poor medium). When each antibody was present at a concentration of 5 µg/ml, the number of living cells declined to approximately 25% after...
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Journal Articles

Lymphocyte Proliferation Is Controlled by both Iron Availability and Regulation of Iron Uptake Pathways

Subject Area:
Further Areas , Oncology , Pathology and Cell Biology
Paul A. Seligman, Jan Kovar, Erwin W. Gelfand
Journal: Pathobiology
Pathobiology (1992) 60 (1): 19–26.
https://doi.org/10.1159/000163692
Published Online: 07 October 2008
... Transferrin synthesis Deferoxamine Gallium Indium Symposium Pathobiology 1992:60:19-26 Paul A. Seligmana Jan Kovarb Erwin W. Gelfand0 ' Division of Hematology. Department of Medicine. University of Colorado Health Sciences Center. Denver, Colo.: b Division of Basic Sciences, Department of Pediatrics...
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