... the expression of costimulatory molecules such as CD86 and CD40 and induces the production of suppressor factors such as the cytokine synthesis inhibitory factor IL-10. On endothelial cells α-MSH is capable of downregulating the LPS-induced expression of adhesion molecules such as vascular cellular adhesion...

.... Endothelial cell HUVEC Organ culture Adhesion molecule CD34 Endothelial nitric oxide synthase Fibrinolysis Tissue plasminogen activator Plasminogen activator inhibitor Tumor necrosis factor-α Original Paper Pathobiology 1999;67:99 107 Received: July 17, 1998 Accepted: August 5, 1998 Comparative...