We tested the antiproliferative effect induced by the natural human tumor necrosis factors α and β (nHuTNF-α, -β) or a combination of these in the clonogenic assay. The antiproliferative effects were evaluated by examining the inhibition of clonogenic growth of RPMI-4788 cells, which had been established from a human colon cancer. TNF-α and -β were natural human types produced by a B cell leukemia line (BALL-1 cells) and were both over 99% pure. The antiproliferative effect in combination of nHuTNF-α and -β was analysed by using the median effect plot and the combination index. The results indicate a synergism between two factors.

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