Human gastric carcinoma showed different growth in nude mice depending on their genetic backgrounds which included BALB/cA-nu (nude mice with a BALB/cA genetic background), CBA/N-nu, NFS/N-nu, NIH(s)-nu, C3H/HeN+-nu, C57BL/6N-nu and lasat mice (BALB/cA-nu, Dh). Rapid growth of human carcinoma was observed in CBA/N-nu, NFS/N-nu and NIH(s)-nu. The human carcinoma in NIH(s)-nu showed the widest deviation in tumor weight. These data suggest that NFS/N-nu and CBA/N-nu are strains which are more recommended for anticancer agent screening systems than BALB/cA-nu, NIH(s)-nu, C3H/HeN+-nu, C57BL/6N-nu and lasat mice, although many other factors including productivity of the mice, strain differences in drug metabolism and drug toxicity must be considered.

Keywords:
Athymic mice, Nude mice, Gastric carcinoma, Tumor growth, Strain difference
This content is only available via PDF.
© 1982 S. Karger AG, Basel
1982
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.