Investigations on cell-mediated immune release of 51Cr from the EL-4 ascitic lymphoma showed that daily rhythmic changes can be correlated with the dominance of certain cell types in the population. Cells in compartment 1 – i.e., those representing true G₀, early G1S and M – are most sensitive to effector cell attack. During the established 96-hour appearance cycle of the population, each day a different compartment will predominate, with corresponding variations in percent immune release. On days when spontaneous 51Cr- release shows a maximum, immune release is minimal. The differences between maximal values of immune release may reach more than 300%, when findings from different days in the appearance cycle are compared.

Keywords:
51Cr immune release, EL-4 ascitic tumor, Population kinetics
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© 1978 S. Karger AG, Basel
1978
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