The intravenous injection of tubercle bacilli in mice results in the deposition of many bacilli in adipose tissue. This implantation occurs earlier in brown fat than in white fat. It does not follow immediately after the injection, but results from the redistribution of some of the bacilli which are, at first, stopped in the lungs. The bacillary multiplication leads to the formation of scattered lesions, which consist of local mesenchymal and adipose cells, joined by macrophages of circulatory origin. The nodular picture appears similar to the pulmonary one, but progresses more slowly. The effects of immunity after a previous immunization are especially noteworthy-, limited bacillary multiplication, delayed necrosis and extensive cellular metaplasia. The involvement of cellular adipose tissue, and in general of mesenchymal tissue, until now little known, doubtlessly plays an important part in the evolution of experimental tuberculosis.

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© 1972 S. Karger AG, Basel
1972
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