The distribution of the metastases of an experimentally produced plasmocytoma (HIPA-tumor) was determined after intravenous, subcutaneous or intraperitoneal inoculation of a defined number of ascites tumor cells into isologous mice. After a latent period of about 17 days following intravenous inoculation osteolytic and osteoplastic metastases were common. These lesions were verified roentgenographically, histologically, and by maceration of gross specimens of bone. Bone metastases were rare after subcutaneous inoculation of neoplastic cells. Pulmonary metastases were equally common after intravenous or subcutaneous inoculation. Intraperitoneal inoculation did not produce extraperitoneal metastases. Incidence and morphological appearance of bone metastases agreed with those of other known experimental plasmocytomas. In contrast to the latter, HIPA-tumor did not give rise to splenic or hepatic metastases. The special position of the HIPA-tumor among murine plasmocytomas was discussed.

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