... to in the content or advertisements. Krüppel-like factor 4 Pancreatic ductal adenocarcinoma Pancreatic intraepithelial neoplasia Laser microdissection Clinical outcome Krüppel-like factor 4 (KLF4) is a member of the KLF family of zinc-finger-containing transcription factors, mapped at 9q22.3–31...

... Pancreatic adenocarcinoma Pancreatic intraepithelial neoplasia Pancreatic adenocarcinoma is the fourth leading cause of cancer death in the United States [ 1 ]. Increasing age, smoking and several genetic mutations including Peutz-Jeghers syndrome have been shown to increase an individual’s risk...

...Ji Kon Ryu; Seung-Mo Hong; Collins A. Karikari; Ralph H. Hruban; Michael G. Goggins; Anirban Maitra Background/Aims: Pancreatic intraepithelial neoplasia (PanIN) is the most common noninvasive precursor to invasive pancreatic adenocarcinoma. Misexpression of microRNAs (miRNAs) is commonly...

.... Pancreatic intraepithelial neoplasia Molecular pathology Tumor markers Pancreatic ductal adenocarcinoma Molecular Diagnosis of Pancreatic Cancer: Review Series Guest Editors: J.P. Neoptolemos (Liverpool); T.M. Gress (Marburg) Pancreatology 2009;9:45 54 DOI: 10.1159/000178874 Published online: December...

... in diameter, the intraductal lesions around a mass were studied histologically and mapped according to the pancreatic intraepithelial neoplasia (PanIN) classification. Results: PanIN-3, PanIN-2, PanIN-1B and PanIN-1A were found in 17, 10, 20 and 21 of 21 cases, respectively, and were divided into lesions...

... the current state of the literature vis-à-vis the three common precursor lesions of pancreatic adenocarcinoma: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. We also discuss two clinical scenarios of emerging importance, namely asymptomatic...

...R. Albazaz; C.S. Verbeke; S.H. Rahman; M.J. McMahon Background: Cyclooxygenase-2 (COX-2) is a key modulatory molecule in inflammation and neoplasia. Increasing evidence suggests a role for COX-2 in pancreatic cancer (PAC). However, expression of COX-2 in pancreatic intraepithelial neoplasia (PanIN...

.... Additionally, we investigated the correlation of PLK1 expression levels with clinicopathological data and patient survival. Results: PLK1 was found overexpressed in pancreatic neoplasia as early as in pancreatic intraepithelial neoplasia III lesions, whereas benign acinar pancreatic parenchyma and ductal...