... incorporating an NF-ĸB-responsive luciferase reporter, with and without adenoviral transduction of DNp38, were stimulated with cholecystokinin (CCK) or tumor necrosis factor-α (TNF-α) prior to measuring NF-ĸB activation. Results: CCK- or TNF-α-stimulated NF-ĸB-dependent gene transcription (luciferase assay...

... ligation are significantly subdued by replacement. In additional in vitro studies, we show that cholecystokinin- or TNF-α-stimulated nuclear transcription factor kappa-B activation in AR42J cells is inhibited by dominant negative ERK2. Conclusions: Our novel findings using our Donor Rat Model indicate...

... placement of pancreatic, biliary, duodenal and venous catheters. Basal and stimulated pancreatic secretions were measured with or without acute alcohol infusion. Pancreatic secretion was stimulated with intravenous bethanechol, 2-deoxy- D -glucose (2-DG), cholecystokinin (CCK), octapeptide (CCK-8...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pancreas Acute pancreatitis Cholecystokinin p38 MAP kinase Stress-activated protein kinase TNF-α Cytokine Signal...

... hyperstimulation via combined CCK-A and cholinergic receptor-mediated pathways. 26 01 2004 27 8 2004 Acute pancreatitis Cholecystokinin Exocrine pancreas Acinar cell Feedback inhibition CCK-A receptor Cholinergic receptor Receptor antagonists Donor rat © 2004 S. Karger AG, Basel...

...Isaac Samuel; Smita Zaheer; Jeffrey J. Nelson; Mark A. Yorek; Asgar Zaheer Bile-pancreatic duct ligation in rats excludes bile-pancreatic juice from the gut and induces acute pancreatitis. Bile-pancreatic juice exclusion from the gut results in increased plasma cholecystokinin (CCK) levels. CCK...

... in acini, the resulting α-amylase secretion and the role of protein kinase C (PKC) activity in these processes. Methods: Freshly isolated acini were treated with different concentrations of ethanol or cholecystokinin octapeptide (CCK-8) for different periods. F-actin was localized by confocal laser...

... stimulate the exocrine pancreas by blunting cholecystokinin release and (2) decrease pain in patients with chronic pancreatitis. Methods: In the first part of the study, on separate days, 6 healthy controls consumed a standard enteral formulation, an enteral formulation containing MCT and hydrolyzed...

... and p125 FAK (extracellular signal-regulated protein kinase and focal adhesion protein kinase, respectively) by cholecystokinin and bombesin stimulation with regard to secretion and mitogenesis. Methods: The p42 ERK2 activity was measured by kinase assay and the activation of p125 FAK...

... 2001 Pancreatitis Inflammation Trypsin activation Cytoskeleton Nuclear factor kappa B Heat shock protein Cerulein Cholecystokinin IAP/APA Meeting Pancreatology 2001;1:356 362 From Acinar Cell Damage to Systemic Inflammatory Response: Current Concepts in Pancreatitis Christoph K. Weber...

...Laurence J. Miller; Xi-Qin Ding The receptor for the peptide hormone, cholecystokinin, is a G-protein-coupled receptor in the rhodopsin/β-adrenergic receptor family. A number of methodological approaches have been utilized to gain insights into the molecular basis for natural peptide ligand binding...

... by cannulation of the pancreatic duct, and pure pancreatic juice was collected. Pancreatic secretion was stimulated by intravenous infusion of cholecystokinin (CCK) (0.06 µg/kg/h) with or without intravenous infusion of glucose (0.25 and 0.5 g/kg/h). The effect of intravenous infusion of glucose (0.5 g/kg/h...

..., the detailed map of neurohormonal regulatory pathways of exocrine pancreatic secretion is yet to be constructed. 24 8 2001 Secretin Cholecystokinin CCK-releasing peptide Secretin-releasing peptide Neuropeptides Serotonin Feedback regulation Vagal afferent pathway Acetylcholine IAP/APA...

..., is stimulated in parallel to the pancreatic enzymes: amylase and trypsin. Amylase Cholecystokinin Estradiol Pancreas Trypsin Vigilin © 2001 S. Karger AG, Basel and IAP 2001 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...